Objectives. The purpose of this study was to examine whether patients with diagnosed hypertension have an increased risk of graft failure following cartilage repair with either autologous chondrocyte implantation (ACI) or osteochondral allograft transplantation (OCA). We hypothesized that hypertension is related to higher ACI and OCA graft failure. Design. Patients who underwent ACI or OCA transplantation between February 2009 and December 2016 were included in this study. Inclusion criteria were (1) at least 2 years' follow-up, (2) available information related to the living habits (smoking and medication status), and (3) available information related to the presence of hypertension, diabetes mellitus, or hyperlipidemia. To identify potential independent risk factors of graft failure, univariate screening was performed and factors with significance at a level of P < 0.1 were entered in multivariate logistic regression models. Results. A total of 368 patients (209 ACI and 159 OCA) were included into our study. In the ACI group, 61 patients' (29.1%) graft failed. Univariate screening identified older age, female gender, defect size, higher prevalence of hypertension, and smoking as a predictor of graft failure. Following, multivariate logistic regression revealed female gender (odds ratio [OR] 1.02, P = 0.048), defect size (OR 1.07, P = 0.035), and hypertension (OR 3.73, P = 0.023) as significant independent risk factors predicting graft failure after ACI. In the OCA group, 29 patients' (18.2%) graft failed and none of the included factors demonstrated to be a potential risk factor for graft failure. Conclusion. Hypertension, defect size, and female gender seem to predict ACI graft failure but not OCA failure.

中文翻译：

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高血压在软骨修复中的作用：自体软骨细胞移植后失败率增加，但同种异体骨软骨移植后失败率增加。

目标。本研究的目的是检查诊断为高血压的患者在使用自体软骨细胞植入 (ACI) 或同种异体骨软骨移植 (OCA) 进行软骨修复后移植失败的风险是否增加。我们假设高血压与较高的 ACI 和 OCA 移植失败有关。设计。本研究纳入了 2009 年 2 月至 2016 年 12 月期间接受 ACI 或 OCA 移植的患者。纳入标准是（1）至少 2 年的随访，（2）与生活习惯（吸烟和药物状况）相关的可用信息，以及（3）与存在高血压、糖尿病或高脂血症相关的可用信息. 为了识别移植失败的潜在独立危险因素，进行了单变量筛选，并将具有 P < 0.1 显着性水平的因素输入到多变量逻辑回归模型中。结果。共有 368 名患者（209 名 ACI 和 159 名 OCA）被纳入我们的研究。在 ACI 组中，61 名患者 (29.1%) 的移植失败。单变量筛查确定了年龄较大、女性性别、缺损大小、高血压患病率较高和吸烟是移植失败的预测因素。随后，多变量逻辑回归显示女性（优势比 [OR] 1.02，P = 0.048）、缺损大小（OR 1.07，P = 0.035）和高血压（OR 3.73，P = 0.023）是预测移植失败的重要独立危险因素ACI 之后。在 OCA 组中，29 名患者 (18.2%) 的移植失败，并且所包含的因素均未证明是移植失败的潜在危险因素。结论。