The effects of infection with Toxoplasma gondii vary from asymptomatic to the development of alterations in various organs (including the liver and kidneys) which may be irreversible, and lead to the death of the host. Whereas homeopathy is an alternative and effective method for treating various diseases, including those caused by protozoa, we questioned the effect of using Lycopodium clavatum in mice infected with T. gondii. One hundred male Swiss mice, 60 days old, were divided into four groups (n = 25/group): NIC (uninfected and untreated control), IC (infected and treated with un-dynamized 7% alcohol solution [vehicle]), G48 (infected and treated 48 h before infection and treated three more times; at 2, 4, and 6 days post-infection (dpi) with L. clavatum 200dH), and G72 (infected and treated for 3 consecutive days before infection with L. clavatum 200dH). In this study, physiological, histopathological, and immunological parameters were evaluated. The L. clavatum 200dH intensified renal damage in mice infected with T. gondii from 7 dpi, causing severe and progressive alterations during this period, such as various degrees of inflammation, edema, atrophy, and tubular cystic dilation, degenerated tubules with intra-cytoplasmic vacuoles and coalescing spots, severe vascular lesions, glomerulonephritis, and peri-glomerular congestion. In the G72 animals, which received L. clavatum 200dH, more severe cortex damage was observed (91.66-96.66%) as compared to the IC group (55-80%) and more renal corpuscle, and renal tubule injury was observed (80 ± 5 to 96.7% ± 2.89 of the total area) during all periods, as compared to the IC group (p < 0.05). Both groups presented high liver enzyme levels, and the highest values for AST were observable at 60 dpi. We observed significant increases of type I and III collagen, as well as high levels of TGF-β1 in both organs of the treated animals, the main factor involved in fibrosis in areas damaged by the process. L. clavatum 200dH intensifies kidney and liver alterations in mice infected with T. gondii. Our results reinforce caution when indicating administration schemes and dosages for ultra-diluted drugs.

中文翻译：

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用200dH狼尾草进行治疗会增强感染弓形虫的小鼠的肾脏和肝损伤。

弓形虫感染的影响从无症状到各种器官（包括肝脏和肾脏）变化的发展，这些变化可能是不可逆的，并导致宿主死亡。顺势疗法是一种可替代的有效方法，可用于治疗包括原生动物在内的各种疾病，但我们对在刚地弓形虫感染的小鼠中使用蛤仔石蒜的效果提出了质疑。将一百只60天大的雄性瑞士小鼠分为四组（n = 25 /组）：NIC（未感染和未治疗的对照），IC（被未动态化7％酒精溶液感染和治疗的[媒介物]，G48） （感染前48小时感染并治疗，再治疗3次；在感染后第2天，4天和6天（C. Clavatum 200dH）处理）和G72（感染前连续3天感染并治疗L. clavatum 200dH）。在这项研究中，评估了生理，组织病理学和免疫学参数。L. clavatum 200dH会从7 dpi起加剧感染弓形虫的小鼠的肾损伤，在此期间引起严重和进行性改变，例如不同程度的炎症，水肿，萎缩和肾小管囊性扩张，具有胞浆内的变性小管空泡和合并点，严重的血管病变，肾小球肾炎和肾小球周围充血。与接受IC组（55-80％）相比，在接受了L. clavatum 200dH的G72动物中，观察到更严重的皮质损伤（91.66-96.66％），并且肾小球更多，并且观察到肾小管损伤（80±与IC组相比，所有期间的总面积的5％至96.7％±2.89％（p <0.05）。两组均表现出较高的肝酶水平，在60 dpi时可观察到最高的AST值。我们观察到在治疗动物的两个器官中，I型和III型胶原蛋白显着增加，以及高水平的TGF-β1，这是该过程破坏区域纤维化的主要因素。L. clavatum 200dH可增强感染弓形虫的小鼠的肾脏和肝脏改变。当指示超稀释药物的给药方案和剂量时，我们的结果加强了谨慎性。贡迪 当指示超稀释药物的给药方案和剂量时，我们的结果加强了谨慎性。贡迪 当指示超稀释药物的给药方案和剂量时，我们的结果加强了谨慎性。