Acute stress induces tissue damage through excessive cellular apoptosis. In our study, the effects of sesamin on apoptosis and wound healing were investigated. The angiogenesis effect of sesamin was evaluated by the abilities of adherence, migration and tube formation in human umbilical vein endothelial cells (HUVECs). Our data demonstrated that treatment with sesamin dose-dependently promoted the proliferation, adherence, migration and enhanced their angiogenic ability in vitro. Moreover, the increased apoptosis in HUVECs, which stimulated by tert-butyl hydroperoxide (TBHP) was significantly attenuated by the sesamin treatment. Furthermore, we revealed that neogenesis of granulation tissue and deposition and remodeling of the collagen matrix were accelerated by the administration of sesamin in our in vivo study. These results confirm that sesamin accelerates wound healing at least partly through its antiapoptotic effects on endothelial cells at the injury site. Thus, sesamin represents a potential therapeutic medicine for vessel injury-related wounds.

中文翻译：

---

芝麻素通过减轻 TBHP 诱导的人脐静脉内皮细胞凋亡来促进血管生成并加速大鼠伤口愈合。


急性应激通过过度细胞凋亡诱导组织损伤。在我们的研究中，研究了芝麻素对细胞凋亡和伤口愈合的影响。通过人脐静脉内皮细胞（HUVEC）的粘附、迁移和成管能力评价芝麻素的血管生成作用。我们的数据表明，芝麻素治疗剂量依赖性地促进增殖、粘附、迁移并增强其体外血管生成能力。此外，芝麻素处理显着减弱了叔丁基过氧化氢（TBHP）刺激的HUVEC细胞凋亡增加。此外，我们发现，在我们的体内研究中，施用芝麻素可加速肉芽组织的新生以及胶原蛋白基质的沉积和重塑。这些结果证实，芝麻素至少部分通过其对损伤部位内皮细胞的抗凋亡作用来加速伤口愈合。因此，芝麻素代表了血管损伤相关伤口的潜在治疗药物。