INTRODUCTION Kikuchi-Fujimoto disease (KFD) may have an autoimmune etiology and some cases have been associated with silicone breast implants. Cytomorphologic features of the disease have been well characterized by fine-needle aspiration of lymph nodes. They are so specific as to permit a precise cytologic diagnosis. Cytologic features have not been reported in fluid specimens. CASE A 33-year-old female presented with a unilateral periprosthetic silicone breast seroma. The fluid was drained, and cytological analysis revealed numerous lymphocytes with no neutrophils, karyorrhectic nuclear debris, and peculiar histiocytes with eccentrically located nuclei showing a crescentic shape. Many of those histiocytes showed intracellular apoptotic debris. CONCLUSION A Kikuchi disease-like inflammatory reaction is possible not only in axillary and cervical lymph nodes of patients with silicone breast implants but also in breast seromas. There is still not enough evidence to establish if there is an association between KFD and breast implants. A detailed cytologic examination of periprosthetic silicone breast seromas may help answer this question. In any case, pathologists must be aware of this possibility. Cytologic features are characteristic enough to permit differentiation from breast implant-associated anaplastic large-cell lymphoma.

中文翻译：

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硅胶乳房植入物血清中的菊池-藤本疾病-炎症反应。

简介菊池藤本病（KFD）可能具有自身免疫病因，有些病例与硅胶乳房植入物有关。该疾病的细胞形态学特征已被细针抽吸淋巴结很好地表征。它们如此特异，可以进行精确的细胞学诊断。尚未在液体样本中报告细胞学特征。案例一名33岁女性，表现为单侧假体周围硅胶乳腺血清肿。排干液体，细胞学分析显示大量无嗜中性粒细胞的淋巴细胞，核功放核碎片和偏心定位的核呈新月形的特殊组织细胞。这些组织细胞中许多都显示细胞内凋亡碎片。结论Kikuchi样炎症反应不仅可能发生在有硅胶乳房植入物的患者的腋窝和颈淋巴结中，而且可能发生在乳腺浆瘤中。仍然没有足够的证据来确定KFD和乳房植入物之间是否存在关联。假体周围硅胶乳房血清肿的详细细胞学检查可能有助于回答这个问题。无论如何，病理学家必须意识到这种可能性。细胞学特征具有足够的特征，可以与乳房植入物相关的间变性大细胞淋巴瘤区分开。假体周围硅胶乳房血清肿的详细细胞学检查可能有助于回答这个问题。无论如何，病理学家必须意识到这种可能性。细胞学特征具有足够的特征，可以与乳房植入物相关的间变性大细胞淋巴瘤区分开。假体周围硅胶乳房血清肿的详细细胞学检查可能有助于回答这个问题。无论如何，病理学家必须意识到这种可能性。细胞学特征具有足够的特征，可以与乳房植入物相关的间变性大细胞淋巴瘤区分开。