This case report describes the clinical presentation, and the diagnostic and therapeutic approaches of a 4-year-old gelding presented with severe polyuria and polydipsia. The horse was diagnosed with central diabetes insipidus. After diagnosis, different therapeutic regimens with intraocular desmopressin acetate (Minirin, Ferring GmbH, Kiel, Germany) (a synthetic arginine vasopressin analog) were tested, but without success. Only the subcutaneous injection of desmopressin acetate (Minirin, Ferring GmbH) led to an increase in urine specific gravity and a decrease in water intake and urine output. Daily subcutaneous treatment with desmopressin acetate (Minirin, Ferring GmbH) was initiated and maintained for at least 5 years. The horse did not develop adverse effects or re-occurrence of the initial complaints. This case report describes successful long-term treatment of central diabetes insipidus in a horse.

中文翻译：

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患有中枢性尿崩症的马的长期激素替代治疗。

该病例报告描述了出现严重多尿和多饮的4岁胶凝症的临床表现以及诊断和治疗方法。这匹马被诊断出患有中枢性尿崩症。诊断后，测试了使用眼内醋酸去氨加压素（Minirin，Ferring GmbH，基尔，德国）（合成的精氨酸加压素类似物）的不同治疗方案，但未成功。仅皮下注射醋酸去氨加压素（Minirin，Ferring GmbH）导致尿比重增加，水摄入和尿量减少。开始使用醋酸去氨加压素（Minirin，Ferring GmbH）进行每日皮下治疗，并维持至少5年。这匹马没有出现不良反应或最初的抱怨再次发生。