This study aimed to evaluate the safety and effectiveness of CT-guided percutaneous cryoablation for treatment of painful osteolytic bone metastases. A total of 26 patients (36 bone metastases) treated with CT-guided percutaneous cryoablation between May 2012 and June 2016 were enrolled in this retrospective study. All procedures were performed under local anesthesia. A visual analog scale (VAS) was used to evaluate pain before the procedure and at 1 day, 1 month, 3 months, and 6 months after the procedure. Complications during and after the procedure were recorded and graded by the Clavien-Dindo classification. The mean VAS pain score was 7.1 ± 1.1 (range, 4-10) before cryoablation. It was significantly lower at all timepoints after treatment: 2.1 ± 1.7 (P < 0.0001) at 1 day after treatment, 1.3 ± 1.8 (P < 0.0001) at 1 month, 1.6 ± 1.7 (P < 0.0001) at 3 months, and 1.8 ± 1.3 (P < 0.0001) at 6 months. The response rates were 91.7%, 94.4%, 91.7%, and 94.4%, respectively, at 1 day, 1 month, 3 months, and 6 months after cryoablation; the complete response rates were 22.2%, 41.7%, 36.1%, and 22.2%, respectively. Adverse events (skin frostbite, nerve injury, pathologic fracture) occurred in 3 patients. CT-guided percutaneous cryoablation under local anesthesia appears to be a safe and effective treatment for painful osteolytic bone metastases. Prospective clinical trials on large samples needed to confirm this conclusion.

中文翻译：

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CT引导下经皮冷冻消融治疗痛性溶骨性骨转移的回顾性分析

本研究旨在评估 CT 引导下经皮冷冻消融术治疗疼痛性溶骨性骨转移的安全性和有效性。2012 年 5 月至 2016 年 6 月期间，共有 26 名接受 CT 引导下经皮冷冻消融治疗的患者（36 处骨转移）纳入了这项回顾性研究。所有手术均在局部麻醉下进行。使用视觉模拟量表 (VAS) 评估手术前和手术后 1 天、1 个月、3 个月和 6 个月的疼痛。手术期间和之后的并发症由 Clavien-Dindo 分类记录和分级。冷冻消融前的平均 VAS 疼痛评分为 7.1 ± 1.1（范围，4-10）。治疗后所有时间点均显着降低：治疗后 1 天 2.1 ± 1.7 (P < 0.0001)，治疗 1 个月时 1.3 ± 1.8 (P < 0.0001)，1.6 ± 1。3 个月时为 7 (P < 0.0001)，6 个月时为 1.8 ± 1.3 (P < 0.0001)。冷冻消融后1天、1个月、3个月和6个月的缓解率分别为91.7%、94.4%、91.7%和94.4%；完全缓解率分别为 22.2%、41.7%、36.1% 和 22.2%。3例患者发生不良事件（皮肤冻伤、神经损伤、病理性骨折）。局部麻醉下 CT 引导的经皮冷冻消融术似乎是治疗疼痛性溶骨性骨转移的一种安全有效的方法。需要对大样本进行前瞻性临床试验来证实这一结论。分别为 2%。3例患者发生不良事件（皮肤冻伤、神经损伤、病理性骨折）。局部麻醉下 CT 引导的经皮冷冻消融术似乎是治疗疼痛性溶骨性骨转移的一种安全有效的方法。需要对大样本进行前瞻性临床试验来证实这一结论。分别为 2%。3例患者发生不良事件（皮肤冻伤、神经损伤、病理性骨折）。局部麻醉下 CT 引导的经皮冷冻消融术似乎是治疗疼痛性溶骨性骨转移的一种安全有效的方法。需要对大样本进行前瞻性临床试验来证实这一结论。