ABSTRACT

Background: Psoriatic Arthritis (PsA) is a seronegative spondyloarthropathy frequently associated with psoriasis. Studies have shown different members of the KIR (Killer Immunoglobulin-like Receptor) gene family may act as potential susceptibility factors; however, data have been inconsistent or with a reduced sample size. Therefore, the objective of this investigation was to determine associations between KIR genes and PsA susceptibility a meta-analysis approach.

Methods: We performed a systemic search on PubMed, Scopus, and Web of Science to identify association studies linking KIR genes with PsA susceptibility. The search cut-off was May 2019. Odds Ratio (OR), 95% Confidence Intervals (95% CI), and forest plots were obtained for each KIR gene. Publication bias was evaluated by Begg and Egger linear regression tests.

Results: Five articles were included in this meta-analysis. The KIR2DL2, 2DS1, 2DS2, and 2DS3 genes were positively associated with susceptibility to PsA (OR = 1.269, p = .003; OR = 1.392, p < .001; OR = 1.279, p = .002; and OR = 1.230, p = .038, respectively). In Caucasians, positive association with susceptibility to PsA were maintained by KIR2DL2, 2DS1, and 2DS2 genes (OR = 1.257, p = .005; OR = 1.535, p = .003; and OR = 1.267, p = .004, respectively).

Conclusion: These associations suggest that KIR2DL2, 2DS1, 2DS2, and 2DS3 genes are susceptibility factors for PsA.

摘要

背景：银屑病关节炎 (PsA) 是一种血清阴性脊柱关节病，常与银屑病相关。研究表明，KIR（杀手免疫球蛋白样受体）基因家族的不同成员可能是潜在的易感因素；然而，数据不一致或样本量减少。因此，本研究的目的是通过荟萃分析方法确定KIR基因与 PsA 易感性之间的关联。

方法：我们对 PubMed、Scopus 和 Web of Science 进行了系统搜索，以确定将KIR基因与 PsA 易感性联系起来的关联研究。搜索截止日期为 2019 年 5 月。获得每个KIR基因的优势比 (OR)、95% 置信区间 (95% CI) 和森林图。通过 Begg 和 Egger 线性回归测试评估发表偏倚。

结果：本荟萃分析包括五篇文章。的KIR2DL2，2DS1，2DS2和2DS3基因呈正易感性相关PSA（OR = 1.269，p = 0.003; OR = 1.392，p <0.001; OR = 1.279，p = 0.002;和OR = 1.230，p = .038，分别）。在白种人中，KIR2DL2、2DS1和2DS2基因维持与 PsA 易感性的正相关（分别为 OR = 1.257，p = .005；OR = 1.535，p = .003；和 OR = 1.267，p = .004） .

结论：这些协会表明，KIR2DL2，2DS1，2DS2和2DS3基因易感因素的PsA。