Currently, pulse wave velocity (PWV) is an important physical index for characterizing the mechanical properties of arteries. Carotid-femoral PWV (cfPWV) is a clinically-approved parameter for evaluating the cardiovascular risk and therapeutic efficacy. However, cfPWV only provides global information about vessel properties. Many recent studies have indicated that local PWV measurements provide precise evaluation of artery conditions. Here, an ultrasound (US) method based on a novel vessel displacement waveform correction, is proposed for improving the accuracy of local carotid PWV measurement. A programmable US device and a commercial array transducer were used, which allow a user to excite transducer and receive US signals arbitrarily with different beam settings. The local PWV measurement accuracy was verified using a phantom. The number of US beams used for PWV measurements was also considered, which indicates that eight elements is the acceptable setting. Subsequently, local carotid PWV and cfPWV were measured in 35 healthy human subjects (age: 21.9 ± 2.4 years) by using the US method and SphygmoCor device, respectively. The cfPWV and local carotid PWV were 6.65 ± 0.74 and 4.63 ± 0.57 m/s, respectively. A good linear correlation was observed between the two aforementioned methods (r = 0.8) for the subjects. All the results indicated that when few US beams were used, the proposed method exhibited a reliable measurement of local PWV.

中文翻译：

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使用基于超声的方法测量颈动脉局部脉搏波速度

目前，脉搏波速度（PWV）是表征动脉机械性能的重要物理指标。颈股动脉 PWV (cfPWV) 是临床批准的用于评估心血管风险和治疗效果的参数。但是，cfPWV 仅提供有关船舶属性的全局信息。最近的许多研究表明，局部 PWV 测量提供了对动脉状况的精确评估。在这里，提出了一种基于新型血管位移波形校正的超声 (US) 方法，以提高局部颈动脉 PWV 测量的准确性。使用可编程 US 设备和商用阵列换能器，允许用户激发换能器并使用不同的光束设置任意接收 US 信号。使用体模验证了局部 PWV 测量精度。还考虑了用于 PWV 测量的 US 光束数量，这表明八个元素是可接受的设置。随后，分别使用美国方法和 SphygmoCor 装置测量了 35 名健康人类受试者（年龄：21.9 ± 2.4 岁）的局部颈动脉 PWV 和 cfPWV。cfPWV 和局部颈动脉 PWV 分别为 6.65 ± 0.74 和 4.63 ± 0.57 m/s。在受试者的上述两种方法（r = 0.8）之间观察到良好的线性相关性。所有结果表明，当使用很少的美国光束时，所提出的方法表现出对局部 PWV 的可靠测量。4 年）分别使用 US 方法和 SphygmoCor 设备。cfPWV 和局部颈动脉 PWV 分别为 6.65 ± 0.74 和 4.63 ± 0.57 m/s。在受试者的上述两种方法（r = 0.8）之间观察到良好的线性相关性。所有结果表明，当使用很少的美国光束时，所提出的方法表现出对局部 PWV 的可靠测量。4 年）分别使用 US 方法和 SphygmoCor 设备。cfPWV 和局部颈动脉 PWV 分别为 6.65 ± 0.74 和 4.63 ± 0.57 m/s。在受试者的上述两种方法（r = 0.8）之间观察到良好的线性相关性。所有结果表明，当使用少量 US 光束时，所提出的方法表现出对局部 PWV 的可靠测量。