The review by Toshchakov and Javmen provides a comprehensive and authoritative perspective on the current state of development of cell-permeable peptide inhibitors of TLR signaling, the field to which the authors have become major contributors. The subject of this manuscript is important not only because of the importance of TLR in health and disease, but also because this approach might present a comprehensive strategy to targeting a potentially wide range of medically important signaling pathways. Although cell-permeable peptides have not found a clinical use yet, the results obtained in small animal models are quite striking and clearly demonstrate potential of this approach for development of candidate drugs or drug leads.

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编辑选择。

Toshchakov和Javmen的评论对TLR信号的细胞可渗透肽抑制剂的发展现状提供了全面而权威的观点，该领域的作者已成为该领域的主要贡献者。该手稿的主题很重要，不仅因为TLR在健康和疾病中的重要性，而且因为这种方法可能会提出一种针对可能具有广泛医学意义的信号通路的综合策略。尽管细胞渗透性肽尚未发现临床用途，但在小动物模型中获得的结果非常惊人，并清楚地证明了这种方法在开发候选药物或药物先导中的潜力。