Appropriate organization of cytoskeletal components are required for normal distribution and intracellular localization of different ion channels and proteins involved in calcium homeostasis, signal transduction, and contractile function of striated muscle. Proteins of the contractile system are in direct or indirect connection with the extrasarcomeric cytoskeleton. A number of other molecules which have essential role in regulating stretch-, voltage-, and chemical signal transduction from the surface into the cytoplasm or other intracellular compartments are already well characterized. Sarcomere, the basic contractile unit, is comprised of a precisely organized system of thin (actin), and thick (myosin) filaments. Intermediate filaments connect the sarcomeres and other organelles (mitochondria and nucleus), and are responsible for the cellular integrity. Interacting proteins have a very diverse function in coupling of the intracellular assembly components and regulating the normal physiological function. Despite the more and more intense investigations of a new cytoskeletal protein family, the septins, only limited information is available regarding their expression and role in striated, especially in skeletal muscles. In this review we collected basic and specified knowledge regarding this protein group and emphasize the importance of this emerging field in skeletal muscle biology.

参与钙稳态、信号转导和横纹肌收缩功能的不同离子通道和蛋白质的正常分布和细胞内定位需要细胞骨架成分的适当组织。收缩系统的蛋白质与肌节外细胞骨架直接或间接相关。许多其他分子在调节从表面到细胞质或其他细胞内区室的拉伸、电压和化学信号转导方面具有重要作用，这些分子已经得到很好的表征。肌节是基本的收缩单位，由精确组织的细（肌动蛋白）和粗（肌球蛋白）细丝系统组成。中间丝连接肌节和其他细胞器（线粒体和细胞核），并负责细胞的完整性。相互作用的蛋白质在细胞内组装成分的偶联和调节正常生理功能方面具有非常多样化的功能。尽管对一个新的细胞骨架蛋白家族——septins 进行了越来越深入的研究，但关于它们在横纹肌中的表达和作用，尤其是在骨骼肌中，只有有限的信息可用。在这篇综述中，我们收集了关于这一蛋白质组的基础知识和特定知识，并强调了这一新兴领域在骨骼肌生物学中的重要性。关于它们在横纹肌中的表达和作用，特别是在骨骼肌中，只有有限的信息可用。在这篇综述中，我们收集了关于这一蛋白质组的基础知识和特定知识，并强调了这一新兴领域在骨骼肌生物学中的重要性。关于它们在横纹肌中的表达和作用，特别是在骨骼肌中，只有有限的信息可用。在这篇综述中，我们收集了关于这一蛋白质组的基础知识和特定知识，并强调了这一新兴领域在骨骼肌生物学中的重要性。