BACKGROUND Associations of polymorphisms in interferon-gamma (IFNG), interleukin-10 (IL-10), and interleukin-18 (IL-18) with coronary artery disease (CAD) have already been investigated by many studies, yet the findings of these studies have been somewhat inconsistent. OBJECTIVES The aim of this meta-analysis was to better clarify associations between polymorphisms in IFNG/IL-10/IL-18 and CAD by combing the results of all relevant articles. METHODS Eligible articles were searched from PubMed, EMBASE, WOS, and CNKI. We used Review Manager to combine the results of indi-vidual studies. RESULTS Fifty-one studies were included in this meta-analysis. Combined results revealed that IFNG rs243056, IL-10rs1800871, IL-18rs187238, IL-18rs1946518, and IL-18rs1946519 polymorphisms were all significantly associated with CAD in the general population. We also obtained similar significant results for IFNG rs243056, IL-10rs1800871, IL-10 rs1800896, IL-18rs187238, IL-18rs1946518, and IL-18rs1946519 polymorphisms in Asians in further subgroup analyses. CONCLUSIONS Collectively, this meta-analysis proved that IFNG rs243056, IL-10rs1800871, IL-10 rs1800896, IL-18rs187238, IL-18rs1946518, and IL-18rs1946519 polymorphisms may confer susceptibility to CAD for Asians.

中文翻译：

---

七个常见细胞因子基因多态性与冠状动脉疾病之间的关联：来自荟萃分析的证据。

背景技术许多研究已经研究了干扰素-γ（IFNG），白介素-10（IL-10）和白介素-18（IL-18）多态性与冠状动脉疾病（CAD）的关联，但是这些发现研究有些不一致。目的本荟萃分析的目的是通过合并所有相关文章的结果，更好地阐明IFNG / IL-10 / IL-18中的多态性与CAD之间的关联。方法从PubMed，EMBASE，WOS和CNKI中检索符合条件的文章。我们使用了“评论管理器”来组合单个研究的结果。结果该荟萃分析包括五十一项研究。组合结果显示，在一般人群中，IFNG rs243056，IL-10rs1800871，IL-18rs187238，IL-18rs1946518和IL-18rs1946519多态性均与CAD显着相关。在进一步的亚组分析中，我们还获得了亚洲人的IFNG rs243056，IL-10rs1800871，IL-10 rs1800896，IL-18rs187238，IL-18rs1946518和IL-18rs1946519多态性相似的重要结果。结论总体而言，该荟萃分析证明，IFNG rs243056，IL-10rs1800871，IL-10 rs1800896，IL-18rs187238，IL-18rs1946518和IL-18rs1946519多态性可能赋予亚洲人CAD易感性。