Osteoarthritis (OA) is a bone and joint disease characterized by progressive cartilage degradation. In the face of global trends of population aging, OA is expected to become the fourth most common disabling disease by 2020. Nevertheless, the detailed pathogenesis of OA has not yet been elucidated. Noncoding RNAs (ncRNAs), including long noncoding RNAs, microRNAs, and circular RNAs, do not encode proteins but have recently emerged as important regulators of apoptosis and autophagy of chondrocytes, thereby highlighting a potential role in chondrocyte injury leading to OA onset and progression. We here review recent findings on these regulatory roles of ncRNAs to provide new directions for research on the pathogenesis of OA and offer new therapeutic targets for prevention and treatment. This article is categorized under: RNA in Disease and Development > RNA in Disease RNA in Disease and Development > RNA in Development.

中文翻译：

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非编码 RNA：软骨细胞凋亡和自噬的新调控代码。

骨关节炎 (OA) 是一种骨和关节疾病，其特征是进行性软骨退化。面对全球人口老龄化的趋势，预计到2020年OA将成为第四大常见致残性疾病。然而，OA的详细发病机制尚未阐明。非编码 RNA (ncRNA)，包括长非编码 RNA、微小 RNA 和环状 RNA，不编码蛋白质，但最近已成为软骨细胞凋亡和自噬的重要调节因子，从而突出了在导致 OA 发作和进展的软骨细胞损伤中的潜在作用。我们在这里回顾了关于 ncRNA 的这些调节作用的最新发现，为 OA 发病机制的研究提供新的方向，并为预防和治疗提供新的治疗靶点。本文分类如下：