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Heat shock protein 90 inhibition in the inflamed lungs.
Cell Stress and Chaperones ( IF 3.8 ) Pub Date : 2020-01-17 , DOI: 10.1007/s12192-020-01069-1
Nektarios Barabutis 1
Affiliation  

Heat shock protein 90 is a highly conserved molecular chaperone, essential for cellular survival under diverse environments. Since this protein is employed by tumors to promote their prevalence, heat shock protein 90 inhibitors have been developed to oppose malignancies. The anti-cancer effects of those compounds appear to be associated with anti-inflammatory properties. Thus, ongoing laborious efforts investigate the possible application of those agents towards inflammatory disorders of the lungs, such as the acute respiratory distress syndrome.

中文翻译:

热激蛋白90抑制发炎的肺部。

热激蛋白90是高度保守的分子伴侣,对于多种环境下的细胞存活至关重要。由于这种蛋白质被肿瘤所利用以提高其患病率,因此已经开发出了热激蛋白90抑制剂来对抗恶性肿瘤。这些化合物的抗癌作用似乎与抗炎特性有关。因此,正在进行的艰苦努力研究了这些试剂对肺部炎症性疾病如急性呼吸窘迫综合征的可能应用。
更新日期:2020-01-17
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