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Heat shock protein 90 inhibition in the inflamed lungs.
Cell Stress and Chaperones ( IF 3.3 ) Pub Date : 2020-01-17 , DOI: 10.1007/s12192-020-01069-1
Nektarios Barabutis 1
Affiliation  

Heat shock protein 90 is a highly conserved molecular chaperone, essential for cellular survival under diverse environments. Since this protein is employed by tumors to promote their prevalence, heat shock protein 90 inhibitors have been developed to oppose malignancies. The anti-cancer effects of those compounds appear to be associated with anti-inflammatory properties. Thus, ongoing laborious efforts investigate the possible application of those agents towards inflammatory disorders of the lungs, such as the acute respiratory distress syndrome.

中文翻译:


热休克蛋白 90 对发炎的肺部有抑制作用。



热休克蛋白 90 是一种高度保守的分子伴侣,对于细胞在不同环境下的生存至关重要。由于肿瘤利用这种蛋白质来促进其患病率,因此已开发出热休克蛋白 90 抑制剂来对抗恶性肿瘤。这些化合物的抗癌作用似乎与抗炎特性有关。因此,正在进行的艰苦努力调查这些药物治疗肺部炎症性疾病(例如急性呼吸窘迫综合征)的可能性。
更新日期:2020-01-17
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