Antimicrobial peptides (AMPs) have been found in all organism taxa and may play an essential role as a host defense system. AMPs are organized in various conformations, such as linear peptides, disulfide bond-linked peptides, backbone-linked peptides and circular peptides. AMPs apparently act primarily on the plasma membrane, although an increasing number of works have shown that they may also target various intracellular sites. Spider venoms are rich sources of biomolecules that show several activities, including modulation or blockage of ion channels, anti-insect, anti-cancer, antihypertensive and antimicrobial activities, among others. In spider venoms from the Lycosidae family there are many linear AMPs with a wide range of activities against several microorganisms. Due to these singular activities, some Lycosidae AMPs have been modified to improve or decrease desirable or undesirable effects, respectively. Such modifications, especially with the aim of increasing their antibiotic activity, have led to the filing of many patent applications. This review explores the abundance of Lycosidae venom AMPs and some of their derivatives, and their use as new drug models.

在所有生物类群中都发现了抗菌肽（AMP），它可能在宿主防御系统中发挥重要作用。AMP以各种构象组织，例如线性肽，二硫键连接的肽，主链连接的肽和环状肽。AMP显然主要作用于质膜，尽管越来越多的研究表明它们也可能靶向多种细胞内位点。蜘蛛毒液是生物分子的丰富来源，具有多种活性，包括调节或阻断离子通道，抗昆虫，抗癌，抗高血压和抗微生物活性等。在狼蛛科的蜘蛛毒液中，存在许多线性AMP，它们对多种微生物具有广泛的活性。由于这些特殊的活动，某些狼科AMPs已经被修饰以分别改善或减少期望或不期望的作用。这种修饰，特别是为了增加其抗生素活性，已经导致提交了许多专利申请。这篇综述探讨了狼毒蛇毒AMPs及其一些衍生物的丰富性，以及它们作为新药模型的用途。