Triple-Negative Breast Cancer (TNBC), represents a subtype of breast cancer in which the estrogens receptor (ER) negative, the progesterone receptor (PR) negative and the human epidermal growth factor receptor 2 (HER2) negative, are not expressed. Thusly, TNBC does not respond to hormonal therapies or to those targeting the HER2 protein receptors. To overcome this flawed issue, new alternative therapies based on the use of natural substances, as the (−) - epigallocatechin 3-gallate (EGCG), has been proposed. It is largely documented that EGCG, the principal constituent of green tea, has suppressive effects on different types of cancer, including breast cancer, through the regulation of different signaling pathways. Thus, is reasonable to assume that EGCG could be viewed as a therapeutic option for the prevention and the treatment of TNBC. Here, we summarizing these promising results with the scope of turn a light on the potential roles of EGCG in the treatment of TNBC patients.

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关于 EGCG 在三阴性乳腺癌中的抗癌作用的最新证据：当前知识状态的更新

三阴性乳腺癌 (TNBC) 是一种乳腺癌亚型，其中雌激素受体 (ER) 阴性、孕激素受体 (PR) 阴性和人表皮生长因子受体 2 (HER2) 阴性，均未表达。因此，TNBC 对激素疗法或靶向 HER2 蛋白受体的疗法没有反应。为了克服这个有缺陷的问题，已经提出了基于使用天然物质的新替代疗法，如 (-) - 表没食子儿茶素 3-没食子酸酯 (EGCG)。大量文献证明，绿茶的主要成分 EGCG 通过调节不同的信号通路对包括乳腺癌在内的不同类型的癌症具有抑制作用。因此，可以合理地假设 EGCG 可被视为预防和治疗 TNBC 的治疗选择。这里，