Proximate causes and consequences of intergenerational influences of salient sensory experience.,Genes, Brain and Behavior

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Proximate causes and consequences of intergenerational influences of salient sensory experience.
Genes, Brain and Behavior ( IF 2.4 ) Pub Date : 2020-01-14 , DOI: 10.1111/gbb.12638
Hadj S Aoued ₁ , Soma Sannigrahi ₁ , Sarah C Hunter ₁ , Nandini Doshi ₁ , Zakia S Sathi ₁ , Anthony W S Chan _{2,

3} , Hasse Walum _{4,

5} , Brian G Dias _{1,

6}

Affiliation

Salient sensory environments experienced by a parental generation can exert intergenerational influences on offspring. While these data provide an exciting new perspective on biological inheritance, questions remain about causes and consequences of intergenerational influences of salient sensory experience. We previously showed that exposing male mice to a salient olfactory experience, like olfactory fear conditioning, resulted in offspring demonstrating a sensitivity to the odor used to condition the paternal generation and possessing enhanced neuroanatomical representation for that odor. In this study, we first injected RNA extracted from sperm of male mice that underwent olfactory fear conditioning into naïve single-cell zygotes and found that adults that developed from these embryos had increased sensitivity and enhanced neuroanatomical representation for the odor (Odor A) with which the paternal male had been conditioned. Next, we found that female, but not male offspring sired by males conditioned with Odor A show enhanced consolidation of a weak single-trial Odor A + shock fear conditioning protocol. Our data provide evidence that RNA found in the paternal germline after exposure to salient sensory experiences can contribute to intergenerational influences of such experiences, and that such intergenerational influences confer an element of adaptation to the offspring. In so doing, our study of intergenerational influences of parental sensory experience adds to existing literature on intergenerational influences of parental exposures to stress and dietary manipulations and suggests that some causes (sperm RNA) and consequences (behavioral flexibility) of intergenerational influences of parental experiences may be conserved across a variety of parental experiences.

中文翻译：

显着的感官经验的代际影响的直接原因和后果。

父母代经历的显着感官环境可对子代产生代际影响。尽管这些数据为生物学遗传学提供了令人兴奋的新视角，但有关显着感官体验的代际影响的原因和后果仍然存在疑问。我们以前的研究表明，将雄性小鼠暴露于显着的嗅觉经验（如嗅觉恐惧条件）会导致后代表现出对用于调节父代的气味的敏感性，并具有增强的神经解剖学表征。在这个研究中，我们首先将经过嗅觉恐惧处理的雄性小鼠精子中提取的RNA注入幼稚的单细胞合子中，发现从这些胚胎发育的成年小鼠对雄性父亲具有的气味（气味A）具有更高的敏感性和神经解剖学表征。被调节。接下来，我们发现被气味A调节的雄性所生的雌性而不是雄性后代表现出对弱的单次试验气味A +休克恐惧条件调节方案的巩固作用。我们的数据提供了证据，即暴露于明显的感官体验后，在父系种系中发现的RNA可能有助于这种体验的代际影响，并且这种代际影响赋予了适应后代的元素。这样，

更新日期：2020-01-14

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