A LuxR-type regulator, AcrR, regulates flagellar assembly and contributes to virulence, motility, biofilm formation, and growth ability of Acidovorax citrulli.,Molecular Plant Pathology

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A LuxR-type regulator, AcrR, regulates flagellar assembly and contributes to virulence, motility, biofilm formation, and growth ability of Acidovorax citrulli.
Molecular Plant Pathology ( IF 4.8 ) Pub Date : 2020-01-14 , DOI: 10.1111/mpp.12910
Wei Guan ₁ , Tielin Wang ₂ , Qi Huang ₃ , Eryuan Tian ₁ , Bo Liu ₁ , Yuwen Yang ₁ , Tingchang Zhao ₁

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LuxR‐type regulators regulate many bacterial processes and play important roles in bacterial motility and virulence. Acidovorax citrulli is a seedborne bacterial pathogen responsible for bacterial fruit blotch, which causes great losses in melon and watermelon worldwide. We identified a LuxR‐type, nonquorum sensing‐related regulator, AcrR, in the group II strain Aac‐5 of A. citrulli. We found that the acrR mutant lost twitching and swimming motilities, and flagellar formation. It also showed reduced virulence, but increased biofilm formation and growth ability. Transcriptomic analysis revealed that 394 genes were differentially expressed in the acrR mutant of A. citrulli, including 33 genes involved in flagellar assembly. Our results suggest that AcrR may act as a global regulator affecting multiple important biological functions of A. citrulli.

中文翻译：

LuxR型调节剂AcrR调节鞭毛的装配，并有助于柠檬酸嗜酸性菌的毒力，运动性，生物膜形成和生长能力。

LuxR型调节剂调节许多细菌过程，并在细菌运动和毒力中发挥重要作用。Acidovorax citrulli是一种种子传播的细菌病原体，可引起细菌性水果斑点，在全球范围内造成大量瓜类和西瓜损失。我们确定了蛋白LuxR型，nonquorum感测相关的调节器，ACRR，在组II株AAC-5的A. citrulli。我们发现acrR突变体失去抽搐和游泳的动力，并形成鞭毛。它还显示出降低的毒力，但增加了生物膜的形成和生长能力。转录组分析表明，394个基因的差异表达的acrR突变A. citrulli，包括鞭毛装配中涉及的33个基因。我们的结果表明，AcrR可能是影响瓜果曲霉多种重要生物学功能的全局调节剂。

更新日期：2020-01-14

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