Enokipodins are antimicrobial sesquiterpenes produced by Flammulina velutipes in a mycelial culture medium. To date, enokipodin production has not been reported in other members of the genus Flammulina. Hence, in this study, the production of enokipodins A, B, C, and D by F. velutipes and F. rossica was investigated. Some strains of F. rossica were confirmed to produce at least one of the four enokipodins in the culture medium. However, some strains of F. velutipes did not produce any of the enokipodins. In an antibacterial assay using liquid medium, enokipodin B showed the strongest growth inhibitory activity against Bacillus subtilis among the four types of enokipodins. Enokipodin B inhibited the spore germination of some plant pathogenic fungi. Enokipodins B and D exerted moderate anti-proliferative activity against some cancer cell lines, and enokipodins A and C inhibited the proliferation of the malarial parasite, Plasmodium falciparum.

中文翻译：

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玫瑰金针菇和金针菇的烯基足蛋白AD的生产率和生物活性。

Enokipodins是金针菇在菌丝体培养基中产生的抗菌倍半萜。迄今为止，在金针菇属的其他成员中尚未报道烯基鬼臼素的产生。因此，在这项研究中，研究了由velutipes和F. rossica生产的烯基鬼臼素A，B，C和D。证实了蔷薇F.rossica的一些菌株在培养基中产生四种enokipodin中的至少一种。但是，某些天鹅绒葡萄球菌菌株没有产生任何烯基脚蛋白。在使用液体培养基的抗菌测定中，enokipodin B在四种类型的enokipodins中显示出对枯草芽孢杆菌最强的生长抑制活性。Enokipodin B抑制某些植物病原真菌的孢子萌发。Enokipodins B和D对某些癌细胞系具有中等程度的抗增殖活性，