Cervical cancer is among the most prevalent malignancies for women. An increasing number of evidences have been proved that long non-coding RNAs (lncRNAs) play significant role in the initiation and progression of cervical cancer. However, the function of long intergenic non-protein coding RNA 319 (LINC00319) in cervical cancer still remains vague. In this study, our purpose was to investigate the effects of LINC00319 on cell migration, invasion and epithelial-mesenchymal transition (EMT) process in cervical cancer. It confirmed that LINC00319 was highly expressed in tissues and cell lines in cervical cancer. Further, overexpression of LINC00319 accelerates cell migration, invasion and EMT in cervical cancer. Moreover, LINC00319 could bind with miR-3127-5p and negatively regulated its expression. Besides, RPP25 was targeted by miR-3127-5p, and its expression was negatively/positively regulated by miR-3127-5p/LINC00319. Additionally, miR-3127-5p mimics or RPP25 insufficiency could offset the encouraging effects of LINC00319 overexpression on migration, invasion and EMT process in cervical cancer. Generally speaking, LINC00319 promotes migration, invasion and EMT process in cervical cancer by regulating miR-3127-5p/RPP25 axis, which may be conductive to cervical cancer treatment.

中文翻译：

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LINC00319通过调节miR-3127-5p / RPP25轴促进宫颈癌的迁移，侵袭和上皮-间质转化过程。

宫颈癌是女性最普遍的恶性肿瘤之一。越来越多的证据表明，长的非编码RNA（lncRNA）在子宫颈癌的发生和发展中起着重要作用。但是，长基因间非蛋白质编码RNA 319（LINC00319）在宫颈癌中的功能仍然不清楚。在这项研究中，我们的目的是研究LINC00319对子宫颈癌细胞迁移，侵袭和上皮间质转化（EMT）过程的影响。证实LINC00319在宫颈癌的组织和细胞系中高表达。此外，LINC00319的过表达可加速子宫颈癌中的细胞迁移，侵袭和EMT。此外，LINC00319可以与miR-3127-5p结合并对其表达负调控。此外，miR-3127-5p靶向RPP25，其表达受到miR-3127-5p / LINC00319的负/正调控。此外，miR-3127-5p模拟物或RPP25功能不足可能抵消了LINC00319过表达对子宫颈癌的迁移，侵袭和EMT过程的令人鼓舞的影响。一般来说，LINC00319通过调节miR-3127-5p / RPP25轴来促进子宫颈癌的迁移，侵袭和EMT过程，这可能有助于子宫颈癌的治疗。