Bladder cancer (BC) is one of the most common human cancers. There is an interest in controlling and treating BC and other types of cancer via the use of natural substances and/or combination chemotherapy. Modified forms of pectin have been reported to possess anticancer bioactivity related to the interaction of galactosyl, a main component of pectin, with galectin-3, a carbohydrate-binding protein that is overexpressed on many types of cancer cells. In this study, the antiproliferative effect on BC of novel modified pectins extracted from olives was evaluated. Pectoliv extracts, with high polyphenol content associated to polysaccharides rich in pectin, exhibited an important antiproliferative capacity in vitro against four human BC cells lines, RT112, T24, J82, and SCaBER. Pectoliv treatment reduced the expression of galectin-1 and galectin-3 and significantly inhibited the agglutination of erythrocytes. Thus, Pectoliv may have the potential for development as a novel galectin-3 inhibitor.

中文翻译：

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富含多酚和修饰的果胶的橄榄提取物对膀胱癌细胞的抗增殖活性。

膀胱癌（BC）是最常见的人类癌症之一。通过使用天然物质和/或联合化疗来控制和治疗BC和其他类型的癌症是令人感兴趣的。据报道，果胶的修饰形式具有与半乳糖基（果胶的主要成分）与半乳糖凝集素3（一种在多种类型的癌细胞中过表达的碳水化合物结合蛋白）之间的相互作用有关的抗癌生物活性。在这项研究中，评估了从橄榄中提取的新型改性果胶对BC的抗增殖作用。富含果胶多糖的多酚含量高的果胶提取物在体外具有重要的抗增殖能力对抗四种人类BC细胞系RT112，T24，J82和SCaBER。Pectoliv处理降低了galectin-1和galectin-3的表达，并显着抑制了红细胞的凝集。因此，Pectoliv可能具有开发新型半乳凝素3抑制剂的潜力。