The objective of the study was to realize whether specific signatures for high-risk human papilloma virus (HPV) infection exist in the cytologic specimens with ASC-US judgement or not. The materials are 132 cytologic specimens with the diagnosis of ASC-US, including 56 cases with positive and 76 cases with negative HPV infection. Cytological findings are compared between two groups. Immature squamous metaplastic cells with nuclear atypia, SFT/IMT dyskaryotic cells, atypical parakeratosis, smudgy nuclei and multinucleated cells are the signature of high-risk HPV infection, whereas in the HPV(−) group immature metaplastic cells without atypia, moderately mature metaplastic cells without nuclear atypia and atrophic background are more popular. Instead, there are no differences on SFT/IMT background, microorganism infection and koilocytosis with or without nuclear atypia in both groups. The specific findings to confirm high-risk HPV infection are realized and the present results will contribute to decrease an unnecessary ASC-US judgement.

中文翻译：

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在有 ASC-US 判断的患者中比较有和没有高危 HPV 感染的标本之间的细胞学结果。

该研究的目的是通过 ASC-US 判断，了解细胞学标本中是否存在高危人乳头瘤病毒 (HPV) 感染的特定特征。材料为132例诊断为ASC-US的细胞学标本，其中HPV感染阳性56例，阴性76例。比较两组的细胞学结果。具有核异型性的未成熟鳞状化生细胞、SFT/IMT 异核细胞、非典型角化不全、脏污的细胞核和多核细胞是高危 HPV 感染的特征，而在 HPV(-) 组中，未成熟的化生细胞没有异型性，中等成熟的化生细胞无核异型和萎缩背景更受欢迎。相反，在 SFT/IMT 背景上没有区别，两组均存在微生物感染和空细胞增多症，伴有或不伴有核异型性。确认高危 HPV 感染的具体发现已经实现，目前的结果将有助于减少不必要的 ASC-US 判断。