Atrial fibrillation (AF) is the most common type of arrhythmia, which undermines cardiac function. Atrial fibrillation is a multi-facet malady and it may occur as a result of other diseases or it may trigger other problems. One of the main complications of AF is stroke due to the possibility of clot formation inside the atrium. However, the possibility of stroke occurrence due to the AF and the location from which an embolus dispatches are subject of debate. Another hypothesis about the embolus formation during AF is thrombus formation in aorta and carotid arteries, embolus detachment and its movement. To investigate the possibility of the latter postulation, the current work suggests a parametric study to quantify the sensitivity of aortic flow to four common AF traits including lack of atrial kick, atrial remodelling, left ventricle systolic dysfunction, and high frequency fibrillation. The simulation was carried out by coupling several in-house codes and ANSYS-CFX module. The results reveal that AF traits lower flow rate at left ventricular outflow tract, which in general lowers blood perfusion to systemic, cerebral and coronary circulations. Consequently, it leads to endothelial cell activation potential (ECAP) increase and variation of flow structure that both suggest predisposed areas to atherogenesis and thrombus formation in different regions in ascending aorta, aortic arch and descending thoracic aorta.

中文翻译：

---

心房颤动对主动脉循环血流分布影响的数值研究。

心房颤动 (AF) 是最常见的心律失常类型，它会破坏心脏功能。心房颤动是一种多方面的疾病，它可能是由其他疾病引起的，也可能引发其他问题。房颤的主要并发症之一是中风，因为可能在心房内形成凝块。然而，由于 AF 导致中风发生的可能性以及栓子发出的位置仍存在争议。关于 AF 期间栓子形成的另一个假设是主动脉和颈动脉中的血栓形成、栓子脱离及其运动。为了研究后一种假设的可能性，目前的工作建议进行一项参数研究，以量化主动脉流量对四种常见 AF 特征的敏感性，包括缺乏心房踢、心房重构、左心室收缩功能障碍和高频颤动。通过耦合几个内部代码和 ANSYS-CFX 模块来进行仿真。结果表明，AF 特征降低了左心室流出道的流速，这通常会降低全身、大脑和冠状动脉循环的血液灌注。因此，它导致内皮细胞活化电位 (ECAP) 增加和血流结构的变化，这两者都表明升主动脉、主动脉弓和胸降主动脉不同区域的动脉粥样硬化形成和血栓形成的易感区域。这通常会降低全身、大脑和冠状动脉循环的血液灌注。因此，它导致内皮细胞活化电位 (ECAP) 增加和血流结构的变化，这两者都表明升主动脉、主动脉弓和胸降主动脉不同区域的动脉粥样硬化形成和血栓形成的易感区域。这通常会降低全身、大脑和冠状动脉循环的血液灌注。因此，它导致内皮细胞活化电位 (ECAP) 增加和血流结构的变化，这两者都表明升主动脉、主动脉弓和胸降主动脉不同区域的动脉粥样硬化形成和血栓形成的易感区域。