Fabricating and designing a scaffold is a complex and highly challenging process in the current scenario. The present study deals with the design and fabrication of electrospun Santa Barbara Amorphous (SBA)-15-incorporated polyvinyl alcohol (PVA) with curcumin, which can be used as a biomimetic nanoscaffold for skin tissue engineering. Curcumin was selected due to its effective anti-microbial and anti-inflammatory properties. SBA-15 was selected for its characteristic drug-carrying potential. Fourier transform infrared spectroscopy and x-ray diffraction characterizations of the fabricated nanofiber demonstrated the interaction of PVA, SBA-15 and curcumin. The scanning electron microscopy results depicted that the nanofiber was highly interconnected with a porous structure mimicking the extracellular matrix. The nanofibrous scaffold showed a higher percentage of cell migration, proliferation, cytocompatibility and biocompatibility with absence of cytotoxicity which was evidenced from the results of MTT assay, cell adhesion and live/dead assay using HaCaT cells. The results of the anti-bacterial test depicted that the synthesized nanofiber forms a potent material for skin wound-healing therapeutics. The in vitro drug release study performed over a period of 80 h revealed a sustained release pattern of curcumin from the SBA-15-incorporated PVA nanofiber. Finally, the in vivo results confirmed that SBA-15-incorporated PVA nanofiber with curcumin showed efficient wound-healing activities.

中文翻译：

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设计和制造含有姜黄素的电纺 SBA-15 掺入 PVA：一种用于皮肤组织工程的仿生纳米支架。

在当前情况下，制造和设计脚手架是一个复杂且极具挑战性的过程。本研究涉及静电纺丝圣巴巴拉无定形 (SBA)-15 掺入姜黄素聚乙烯醇 (PVA) 的设计和制造，可用作皮肤组织工程的仿生纳米支架。选择姜黄素是因为其有效的抗菌和抗炎特性。SBA-15 因其特有的载药潜力而被选中。制备的纳米纤维的傅里叶变换红外光谱和 X 射线衍射表征证明了 PVA、SBA-15 和姜黄素的相互作用。扫描电子显微镜结果表明，纳米纤维与模仿细胞外基质的多孔结构高度互连。MTT 测定、细胞粘附和 HaCaT 细胞活/死测定的结果证明，纳米纤维支架显示出更高百分比的细胞迁移、增殖、细胞相容性和生物相容性，且不存在细胞毒性。抗菌测试的结果表明，合成的纳米纤维形成了用于皮肤伤口愈合治疗的有效材料。为期 80 小时的体外药物释放研究揭示了姜黄素从掺有 SBA-15 的 PVA 纳米纤维中的持续释放模式。最后，体内结果证实，掺有姜黄素的 SBA-15 PVA 纳米纤维表现出有效的伤口愈合活性。