Calcium silicate-based cements are known for their wide applications in dentistry and orthopedics. The alkaline pH (up to 12) of these cements limits their application in other orthopedic areas. In this study, the effect of dicalcium phosphate dihydrate (DCPD) coating on set cement on pH reduction and biocompatibility improvement was examined. Samples with 0 and 10 weight ratio DCPD were prepared and characterized by XRD, FTIR, and SEM. The DCPD coating on the set cement was performed by a 7 d immersion in 1% monocalcium phosphate (MCP) solution and characterized by XRD, FTIR, SEM, and EDX. Also, the compressive strength and cytotoxicity of the samples were tested. The results showed that DCPD coating did not significantly change the compressive strength of the cement, but by decreasing the pH of the culture medium to the physiological range, it led to enhance adhesion, spreading and proliferation of human osteosarcoma cell line (Saos-2). The novel DCPD coated calcium silicate-based cement could be served as a bulk or porous bone substitute and scaffold.

中文翻译：

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新型磷酸钙涂覆的硅酸钙基水泥：体外评估。

硅酸钙基水泥以其在牙科和整形外科中的广泛应用而闻名。这些水泥的碱性pH值（高达12）限制了它们在其他骨科领域的应用。在这项研究中，研究了二水合磷酸二钙（DCPD）涂层对固化水泥对降低pH和改善生物相容性的影响。制备了DCPD重量比为0和10的样品，并通过XRD，FTIR和SEM对其进行了表征。固化水泥上的DCPD涂层通过在1％磷酸一钙（MCP）溶液中浸泡7天来进行，并通过XRD，FTIR，SEM和EDX进行表征。而且，测试了样品的抗压强度和细胞毒性。结果表明，DCPD涂层并没有显着改变水泥的抗压强度，而是通过将培养基的pH值降低至生理范围，它可以增强人骨肉瘤细胞系（Saos-2）的黏附，扩散和增殖。新型的DCPD涂层硅酸钙基水泥可以用作块状或多孔骨替代物和支架。