Studies performed decades ago in the canine and nonhuman primate established the dose response relationships for the hematopoietic acute radiation syndrome in response to mixed neutron/gamma, x-radiation, and Co gamma radiation. There were no published studies that determined the dose response relationships for the gastrointestinal acute radiation syndrome in response to either noted radiation quality. This analysis of a retrospective, unpublished study provided the dose response relationships in a canine model for the acute gastrointestinal syndrome relative to the acute hematopoietic syndrome due to mixed neutron/gamma radiation. Canines were exposed to total-body, steady state, bilateral, 0.40 Gy min, mixed neutron/gamma (5.4:1) radiation from a TRIGA reactor. The average neutron/gamma energy (MeV) was 0.85/0.9, and exposure was reported as midline tissue dose. Medical management was not administered. The mixed neutron/gamma exposure resulted in an estimated LD50/6 of 2.83 Gy [2.76, 2.94] and LD50/30 of 2.16 Gy [2.01, 2.24] for the GI- and H-ARS respectively. The mean survival times for decedents after mixed neutron/gamma exposure approximate to the LD50/6 were 8.5 d, 10.5 d, and 4 d for 2.75 Gy, 2.80 Gy, 3.00, and 3.12 Gy exposures, respectively. The mean survival times for decedents for mixed neutron/gamma exposure approximate to the LD50/30 were 21.3 d and 15.6 d for 2.00 Gy and 2.25 Gy, respectively. Furthermore, the dose response relationships for the acute hematopoietic syndrome due to mixed neutron/gamma exposure (0.85/0.9 MeV; 5.4:1) resulted in an estimated relative biological effectiveness of 1.2 as compared with reference Co gamma radiation.

中文翻译：

---

相对于参考Co-60γ辐射的混合中子/γ犬模型中的急性辐射诱导的GI-ARS和H-ARS：一项回顾性研究。

数十年前在犬类和非人类灵长类动物中进行的研究建立了对混合中子/γ射线，x射线和Coγ射线响应的造血急性放射综合症的剂量反应关系。尚无已发表的研究来确定对任一辐射质量作出反应的胃肠道急性放射综合症的剂量反应关系。这项回顾性，未发表研究的分析提供了犬模型中由于中子/γ混合辐射引起的急性胃肠道综合征相对于急性造血综合征的剂量反应关系。犬在TRIGA反应堆的全身，稳态，双边，0.40 Gy分钟，混合的中子/γ（5.4：1）辐射下暴露。平均中子/伽马能（MeV）为0.85 / 0.9，并以中线组织剂量报告暴露。没有进行医疗管理。混合中子/γ暴露对GI-和H-ARS的估计LD50 / 6分别为2.83 Gy [2.76，2.94]和LD50 / 30为2.16 Gy [2.01、2.24]。中子/γ混合暴露后，死者的平均生存时间大约为LD50 / 6，分别为2.75 Gy，2.80 Gy，3.00和3.12 Gy，分别为8.5 d，10.5 d和4 d。中子/γ混合暴露的后代的平均生存时间约为LD50 / 30，对于2.00 Gy和2.25 Gy分别为21.3 d和15.6 d。此外，由于混合中子/γ暴露（0.85 / 0.9 MeV； 5.4：1）引起的急性造血综合症的剂量反应关系导致与参考Coγ辐射相比估计的相对生物学有效性为1.2。