Memory is no longer a privilege of adaptive immunity. Innate immune cells can exhibit a long-term immune activation after infection or vaccination, which is called "trained immunity." In addition to defense against mycobacterial infection, BCG-induced trained immunity can also exert nonspecific protection, which is regulated by metabolic rewiring and epigenetic reprograming. Enhanced glycolysis and glutamine-driven tricarboxylic acid cycle have been proven to be important metabolic pathways for trained immunity induced by BCG, which is dependent on Akt/mTOR pathway.

中文翻译：

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卡介苗诱导的巨噬细胞免疫训练：葡萄糖代谢的重新编程。

记忆不再是适应性免疫的特权。先天免疫细胞在感染或接种疫苗后可表现出长期的免疫激活作用，这被称为“训练免疫”。除了防御分枝杆菌感染外，BCG诱导的训练免疫还可以发挥非特异性保护作用，这种保护作用由代谢重排和表观遗传重编程来调节。事实证明，增强的糖酵解和谷氨酰胺驱动的三羧酸循环是BCG诱导的训练免疫的重要代谢途径，而BCG依赖于Akt / mTOR途径。