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Delay Maturation in Occipital Lobe in Girls With Inattention Subtype of Attention-Deficit Hyperactivity Disorder
Clinical EEG and Neuroscience ( IF 1.6 ) Pub Date : 2020-01-14 , DOI: 10.1177/1550059419899328
Tung-Ming Chang 1 , Rei-Cheng Yang 2 , Ching-Tai Chiang 3 , Chen-Sen Ouyang 4 , Rong-Ching Wu 5 , Sebastian Yu 6 , Lung-Chang Lin 2, 7
Affiliation  

Attention-deficit hyperactivity disorder (ADHD) is a common childhood neuropsychiatric disorder. Differences in the presentations of ADHD between boys and girls have been well established. Three subtypes of ADHD exist. In addition to sex difference, different mechanisms may underlie different subtypes. The present study enrolled 30 girls with the inattentive subtype of ADHD and 30 age-matched controls. Low-resolution electromagnetic tomography (LORETA) and instantaneous frequency were used to analyze electroencephalography (EEG) for investigating the brain area and EEG bands involved in girls with inattentive ADHD. We found that the instantaneous frequencies in all EEG channels in girls with ADHD were lower than those in controls. Alpha 2 was the only EEG band that showed significant difference in current density between the ADHD and control groups (P = .0014). In the entire brain area, the posterior cingulate cortex, cingulate gyrus, and precuneus demonstrated the most significant difference between the ADHD and control groups. Our results suggest that brain maturation delay in the posterior areas might result in the inattention subtype of ADHD. In addition, posterior cingulate cortex, cingulate gyrus, and precuneus may play a critical role in the pathogenesis of ADHD. Our study provides a new approach method and possible mechanism of girls with inattentive subtype ADHD.

中文翻译:

患有注意力缺陷多动障碍的注意力不集中亚型的女孩枕叶成熟延迟

注意缺陷多动障碍(ADHD)是一种常见的儿童神经精神障碍。男孩和女孩在 ADHD 表现上的差异已经很明确。存在三种多动症亚型。除了性别差异外,不同的机制可能是不同亚型的基础。本研究招募了 30 名患有注意力缺陷多动症亚型的女孩和 30 名年龄匹配的对照组。低分辨率电磁断层扫描 (LORETA) 和瞬时频率用于分析脑电图 (EEG),以研究注意力不集中的多动症女孩的大脑区域和脑电图波段。我们发现 ADHD 女孩所有 EEG 通道的瞬时频率低于对照组。Alpha 2 是唯一显示 ADHD 组和对照组之间电流密度显着差异的 EEG 波段 (P = .0014)。在整个大脑区域,后扣带回皮层、扣带回和楔前叶表现出 ADHD 组和对照组之间最显着的差异。我们的结果表明后部区域的大脑成熟延迟可能导致注意力不集中的 ADHD 亚型。此外,后扣带回皮层、扣带回和楔前叶可能在 ADHD 的发病机制中起关键作用。我们的研究为注意力不集中亚型多动症女孩提供了一种新的处理方法和可能的机制。我们的结果表明后部区域的大脑成熟延迟可能导致注意力不集中的 ADHD 亚型。此外,后扣带回皮层、扣带回和楔前叶可能在 ADHD 的发病机制中起关键作用。我们的研究为注意力不集中亚型多动症女孩提供了一种新的处理方法和可能的机制。我们的结果表明后部区域的大脑成熟延迟可能导致注意力不集中的 ADHD 亚型。此外,后扣带回皮层、扣带回和楔前叶可能在 ADHD 的发病机制中起关键作用。我们的研究为注意力不集中亚型多动症女孩提供了一种新的处理方法和可能的机制。
更新日期:2020-01-14
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