As a type of stress, maternal separation (MS) has been one of the most widely used models in neuropsychiatric research. An increasing number of studies has found that MS not only affects the function of the hypothalamic–pituitary–adrenal axis and hippocampal 5-hydroxytryptamine system, but also causes dysfunction of the central dopamine (DA) system and increases the susceptibility of dopaminergic neurons to pathogenic factors of Parkinson's disease (PD), for instance, 6-hydroxydopamine, thus impairing motor function. We reviewed the impact of MS on the DA system and its correlation with PD and found the following: (1) discrepant effects of MS on the DA system have been reported; (2) MS is a good model to study the impact of stress on the occurrence and development of PD, however, unified modeling criteria of MS are required; (3) correlation between MS and PD may involve the impact of MS on the DA system, which however is not the only connection; (4) intervening measures can block pathways between MS and PD, which provides reference for the prevention of PD in specific populations such as left-behind children.

中文翻译：

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母体分离对多巴胺系统的影响及其与帕金森病的关联。

作为一种压力，母性分离 (MS) 一直是神经精神病学研究中使用最广泛的模型之一。越来越多的研究发现，MS不仅影响下丘脑-垂体-肾上腺轴和海马5-羟色胺系统的功能，还会引起中枢多巴胺（DA）系统功能障碍，增加多巴胺能神经元对致病性的易感性。帕金森病 (PD) 的因素，例如 6-羟基多巴胺，从而损害运动功能。我们回顾了 MS 对 DA 系统的影响及其与 PD 的相关性，发现以下内容： (1) 已报告了 MS 对 DA 系统的差异影响；(2) MS是研究应力对PD发生发展影响的良好模型，但需要MS的统一建模标准；(3) MS和PD的相关性可能涉及MS对DA系统的影响，但这不是唯一的联系；(4)干预措施可以阻断MS与PD之间的通路，为留守儿童等特定人群PD的预防提供参考。