Human herpesviruses 6A and 6B, often referred to collectively as human herpesvirus 6, are a pair of beta-herpesviruses known to cause a variety of clinical syndromes in both immunocompetent and immunocompromised individuals. Most humans are infected with human herpesvirus 6B, and many with human herpesvirus 6A. Primary infection typically occurs in early childhood, although large-scale reviews on the topic are limited. Herein, the authors explore the clinical manifestations of human herpesvirus 6-associated disease in both immunocompetent and immunocompromised pediatric patients, the risk factors for development of human herpesvirus 6-associated neurological disease, the risk of autoimmunity associated with development of active or latent infection, the relevance of human herpesvirus 6-specific diagnostic tests, and the medications used to treat human herpesvirus 6. The goal of this review is to improve the current understanding of human herpesvirus 6 in pediatric populations and to examine the most effective diagnostic and therapeutic interventions in this disease state.

中文翻译：

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儿童HHV-6相关神经系统疾病：流行病学，临床，诊断和治疗注意事项。

人类疱疹病毒6A和6B，通常统称为人类疱疹病毒6，是一对β疱疹病毒，已知会在免疫能力强和免疫功能低下的个体中引起多种临床综合征。大多数人感染了人类疱疹病毒6B，许多人感染了人类疱疹病毒6A。原发性感染通常发生在儿童早期，尽管对该主题的大规模评论有限。本文作者探讨了在免疫能力强和免疫功能低下的小儿患者中人类疱疹病毒6相关疾病的临床表现，人类疱疹病毒6相关神经病发展的危险因素，与活动性或潜伏性感染相关的自身免疫风险，人类疱疹病毒6特异性诊断测试的相关性，