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In vitro pharmacological screening of antioxidant, cytotoxic and enzyme inhibitory activities of Citrus aurantifolia Linn. Dried fruit extract
International Journal of Environmental Health Research ( IF 2.2 ) Pub Date : 2020-01-13 , DOI: 10.1080/09603123.2020.1714558
Gökçe Şeker Karatoprak 1 , Çiğdem Yücel Aşık 2 , Ahmet Çakır 1 , Esra Köngül Şafak 1
Affiliation  

ABSTRACT

The Lime Basra (Citrus aurantifolia Linn., Rutaceae) plant also known as dried lime, and Limoo Omani, is used both as a spice in meals and as an herbal tea in the treatment of some diseases in the Middle East. It was aimed to determine the biological activity screening of the 70% methanol, ethanol extracts and infusion which were prepared from dried fruits. 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2ʹ-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS+) radical scavenging activities, ferric reducing activity, cytotoxicity on A 549, MCF 7 and L929 cell lines and α-amylase inhibitory effects were determined. According to the results, 70% methanol extract was more active in antioxidant activity tests and ethanol extract was more active in cytotoxicity tests. Interestingly both 70% methanol and ethanol extracts were found to have potent hypoglycemic activity. The present findings shed light on the fact that it is important to research and scientifically evaluate plants with traditional medicinal use.



中文翻译:

Citrus aurantifolia Linn 的抗氧化、细胞毒性和酶抑制活性的体外药理学筛选。干果提取物

摘要

Lime Basra ( Citrus aurantifolia Linn., Rutaceae) 植物也被称为干石灰和 Limoo Omani,在中东地区用作膳食香料和治疗某些疾病的凉茶。【摘要】:目的对干果中制备的70%甲醇、乙醇提取物和浸液进行生物活性筛选。1,1-二苯基-2-苦基肼 (DPPH ) 和 2,2ʹ-叠氮基-双(3-乙基苯并噻唑啉-6-磺酸) (ABTS+ ) 自由基清除活性、铁还原活性、对 A 549、MCF 7 和 L929 细胞系的细胞毒性和 α-淀粉酶抑制作用进行了测定。根据结果​​,70% 甲醇提取物在抗氧化活性测试中更活跃,乙醇提取物在细胞毒性测试中更活跃。有趣的是,发现 70% 甲醇和乙醇提取物都具有有效的降血糖活性。目前的研究结果表明,研究和科学评估具有传统药用价值的植物非常重要。

更新日期:2020-01-13
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