Pay-load deliveries across the skin barrier to the systemic circulation have been one of the most challenging delivery options. Necessitated requirements of the skin and facilitated skin layer cross-over delivery attempts have resulted in development of different non-invasive, non-oral methods, devices and systems which have been standardized, concurrently used and are in continuous upgrade and improvements. Iontophoresis, electroporation, sonophoresis, magnetophoresis, dermal patches, nanocarriers, needled and needle-less shots, and injectors are among some of the methods of transdermal delivery. The current review covers the current state of the art, merits and shortcomings of the systems, devices and transdermal delivery patches, including drugs’ and other payloads’ passage facilitation techniques, permeation and absorption feasibility studies, as well as physicochemical properties affecting the delivery through different transdermal modes along with examples of drugs, vaccines, genes and other payloads.

中文翻译：

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非侵入性药物输送技术：透皮药物输送装置，技术和生物医学应用的发展和现状。

穿过皮肤屏障进入全身循环的有效载荷输送一直是最具挑战性的输送选择之一。皮肤的必要要求和便利的皮肤层跨界递送尝试已导致开发了各种非侵入性，非口服的方法，设备和系统，这些方法，设备和系统已经标准化，同时使用并且正在不断升级和改进。离子电渗疗法，电穿孔，超声波治疗，磁泳疗法，皮肤贴剂，纳米载体，针刺和无针注射以及注射器是一些透皮给药方法。当前的审查涵盖了当前的技术水平，系统，设备和透皮贴剂的优缺点，包括药物和其他有效载荷的通过促进技术，渗透和吸收可行性研究，