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Enhanced bioactivity of Zanthoxylum schinifolium fermented extract: Anti-inflammatory, anti-bacterial, and anti-melanogenic activity.
Journal of Bioscience and Bioengineering ( IF 2.3 ) Pub Date : 2020-01-09 , DOI: 10.1016/j.jbiosc.2019.12.003 Se-Won Lee 1 , Jeong-Muk Lim 1 , Harshavardhan Mohan 1 , Kamala-Kannan Seralathan 1 , Yool-Jin Park 2 , Jeong-Ho Lee 3 , Byung-Taek Oh 1
Journal of Bioscience and Bioengineering ( IF 2.3 ) Pub Date : 2020-01-09 , DOI: 10.1016/j.jbiosc.2019.12.003 Se-Won Lee 1 , Jeong-Muk Lim 1 , Harshavardhan Mohan 1 , Kamala-Kannan Seralathan 1 , Yool-Jin Park 2 , Jeong-Ho Lee 3 , Byung-Taek Oh 1
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Fermented extracts have evolved to be a potential alternative to synthetic chemicals, owing to their anti-inflammatory and anti-bacterial properties. This study intends to assess the potential of fermented Zanthoxylum schinifolium extract for use in biomedical applications. Probiotic bacteria, Lactobacillus rhamnosus A6-5, were deployed as a seed culture for fermentation. The fermented extract showed greater tyrosinase inhibitory activity and reduced melanin production (58.3%) compared with the raw extract. Cytotoxicity assay inferred that 500 μg/mL is the ideal non-toxic concentration with maximum cell viability. In addition, DAPI staining did not show any damage to the chromatin structure of the cells. The anti-aging property of the fermented extract was confirmed by a decrease in IL-6 content. The fermented extract showed lower MIC (40 mg/mL) and MBC (60 mg/mL), indicating greater anti-bacterial activity than the raw extract. The results confirmed that the fermented Z. schinifolium extract has high biomedical properties compared with the raw extract and can be used as an ideal skin whitening agent.
中文翻译：
Zanthoxylum schinifolium发酵提取物的增强的生物活性：抗炎，抗菌和抗黑色素生成活性。
发酵提取物由于其抗炎和抗菌特性，已发展成为合成化学品的潜在替代品。这项研究旨在评估发酵的花椒提取物在生物医学应用中的潜力。益生菌鼠李糖乳杆菌A6-5被用作种子培养物进行发酵。与原始提取物相比，发酵提取物显示出更高的酪氨酸酶抑制活性，并减少了黑色素生成（58.3％）。细胞毒性测定表明，500μg/ mL是理想的无毒浓度，具有最大的细胞活力。此外，DAPI染色未显示对细胞染色质结构的任何损害。IL-6含量的降低证实了发酵提取物的抗衰老性能。发酵提取物的MIC（40 mg / mL）和MBC（60 mg / mL）较低，表明其抗菌活性高于原始提取物。结果证实，与原始提取物相比，发酵的五味子提取物具有高的生物医学特性，并且可以用作理想的皮肤增白剂。
更新日期：2020-04-21
中文翻译：
Zanthoxylum schinifolium发酵提取物的增强的生物活性：抗炎，抗菌和抗黑色素生成活性。
发酵提取物由于其抗炎和抗菌特性，已发展成为合成化学品的潜在替代品。这项研究旨在评估发酵的花椒提取物在生物医学应用中的潜力。益生菌鼠李糖乳杆菌A6-5被用作种子培养物进行发酵。与原始提取物相比，发酵提取物显示出更高的酪氨酸酶抑制活性，并减少了黑色素生成（58.3％）。细胞毒性测定表明，500μg/ mL是理想的无毒浓度，具有最大的细胞活力。此外，DAPI染色未显示对细胞染色质结构的任何损害。IL-6含量的降低证实了发酵提取物的抗衰老性能。发酵提取物的MIC（40 mg / mL）和MBC（60 mg / mL）较低，表明其抗菌活性高于原始提取物。结果证实，与原始提取物相比，发酵的五味子提取物具有高的生物医学特性，并且可以用作理想的皮肤增白剂。
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