BACKGROUND We aimed to identify a simple test for excessive calciuresis and predict calcium oxalate (CaOx) disease in Miniature Schnauzers. We investigated the impact of postprandial time on the urine calcium to creatinine ratio (UCa/Cr) in male dogs of this breed, with the goal of improving the utility of the UCa/Cr. HYPOTHESES (1) Significant differences will exist in preprandial and postprandial UCa/Cr between CaOx urolith-forming and control Schnauzers. (2) The UCa/Cr will increase significantly from the first morning baseline at ≥1 postprandial time point(s) in both control and CaOx urolith-forming dogs. (3) Biochemical abnormalities and other variables may be associated with urolith status. ANIMALS Twenty-four male Miniature Schnauzer dogs, consisting of 9 with (urolith formers) and 15 without (controls) CaOx uroliths. METHODS Urine was collected before and 1, 2, 4, and 8 hours after feeding a standardized diet. Receiver operator characteristic curve analysis was performed to identify the UCa/Cr cutoff that most accurately differentiates dogs based on urolith status. RESULTS Urolith formers had significantly higher mean UCa/Cr over the course of 8 hours. The postprandial change in UCa/Cr was not significant at any time point between or within groups. The cutoff UCa/Cr value of 0.06 had a specificity of 93% (95% confidence interval [CI], 80%-100%) and a sensitivity of 56% (95% CI, 21%-86%) for identifying CaOx urolithiasis. CONCLUSIONS AND CLINICAL IMPORTANCE Urolith-forming male Miniature Schnauzers have excessive calciuresis, and the postprandial sampling time up to 8 hours is not critical. This simple urine measurement has potential as a marker of CaOx disease.

中文翻译：

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在有和没有尿石症的男性迷你雪纳瑞犬中餐前和餐后尿钙与肌酐的比值。

背景技术我们旨在确定一种简单的过度降钙测试，并预测小型雪纳瑞犬的草酸钙（CaOx）疾病。我们调查了餐后时间对该种公犬尿钙与肌酐之比（UCa / Cr）的影响，目的是提高UCa / Cr的利用率。假设（1）CaOx形成尿石的雪纳瑞犬和对照组的雪纳瑞犬的餐前和餐后UCa / Cr存在显着差异。（2）对照犬和形成CaOx尿石的犬的餐后时间点≥1，UCA / Cr从第一个早晨基线开始显着增加。（3）生化异常和其他变量可能与尿石状态有关。动物24只雄性迷你雪纳瑞犬，由9只有（尿石形成者）和15只无（对照）CaOx尿石组成。方法：在喂食标准饮食之前，1、2、4和8小时后收集尿液。进行接收者操作员特征曲线分析，以识别根据尿石状态最准确区分狗的UCa / Cr截止值。结果在8小时的过程中，Urolith形成者的平均UCa / Cr明显较高。组间或组内的任何时间点的UCa / Cr餐后变化均不显着。截断的UCa / Cr值为0.06，具有93％的特异性（95％置信区间[CI]，80％-100％），灵敏度为56％（95％CI，21％-86％），可用于识别CaOx尿石症。结论和临床意义形成尿石的雄性迷你雪纳瑞犬具有过度的尿酸，并且餐后采样时间长达8小时并不重要。