During the neonatal period, the brain is susceptible to external influences. Exposure to stressful events during this phase of life influences brain development and impacts adult life. In animals, the maternal deprivation (MD) model is effective in mimicking stress in the early stages of development. In contrast, physical exercise seems to be able to prevent deficits in memory consolidation. Although the effects of chronic exercise in cognition are already well established, little is known about the effects of acute aerobic exercise. Here, male Wistar rats divided into deprived (MD) and nondeprived (NMD) rats were submitted to the object recognition (OR) memory test. Immediately after OR training, some of the rats were submitted to a single aerobic exercise session for 30 minutes. Memory consolidation and persistence were evaluated by retention tests performed 24 h and 7, 14, and 21 days after OR training. We show that a single physical exercise session is able to modulate learning by promoting memory consolidation and persistence in rats with cognitive deficits induced by MD. Hippocampal dopamine levels, measured by HPLC, were not altered after OR training in rats that performed and in rats that did not perform an exercise session; on the other hand, while OR training promoted increase of hippocampal norepinephrine in NMD rats, the MD rats did not present this increase, regardless of the practice or not of exercise.

中文翻译：

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母体剥夺会导致记忆力下降，学习会后进行一次有氧运动可减少记忆力下降。

在新生儿期间，大脑容易受到外界影响。在生命的这个阶段中承受压力事件会影响大脑发育并影响成年生活。在动物中，母体剥夺（MD）模型可以有效地模拟发育早期的压力。相反，体育锻炼似乎能够防止记忆巩固不足。尽管慢性运动对认知的影响已经很明确，但是对急性有氧运动的影响知之甚少。在此，将分为剥夺（MD）和非剥夺（NMD）大鼠的雄性Wistar大鼠接受对象识别（OR）记忆测试。进行OR训练后，立即将一些大鼠进行一次有氧运动，持续30分钟。通过在OR训练后24小时，7、14和21天进行的保留测试评估记忆巩固和持久性。我们表明，单一的体育锻炼能够通过促进记忆增强和持久性具有由MD引起的认知缺陷的大鼠的记忆来调节学习。在进行过运动的大鼠和没有进行运动的大鼠中进行OR训练后，通过HPLC测量的海马多巴胺水平没有改变；另一方面，尽管OR训练可促进NMD大鼠海马去甲肾上腺素的增加，但无论是否进行运动，MD大鼠均未出现这种增加。我们表明，单一的体育锻炼能够通过促进记忆增强和持久性具有由MD引起的认知缺陷的大鼠的记忆来调节学习。在进行过运动的大鼠和没有进行运动的大鼠中进行OR训练后，通过HPLC测量的海马多巴胺水平没有改变；另一方面，尽管OR训练促进了NMD大鼠海马去甲肾上腺素的增加，但无论是否进行运动，MD大鼠均未出现这种增加。我们表明，单一的体育锻炼能够通过促进记忆增强和持久性具有由MD引起的认知缺陷的大鼠的记忆来调节学习。在进行过运动的大鼠和没有进行运动的大鼠中进行OR训练后，通过HPLC测量的海马多巴胺水平没有改变；另一方面，尽管OR训练可促进NMD大鼠海马去甲肾上腺素的增加，但无论是否进行运动，MD大鼠均未出现这种增加。