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Learning to collaborate: bringing together behavior and quantitative genomics.
Journal of Neurogenetics ( IF 1.9 ) Pub Date : 2020-01-10 , DOI: 10.1080/01677063.2019.1710145
Patricka A Williams-Simon 1 , Mathangi Ganesan 1 , Elizabeth G King 1
Affiliation  

The genetic basis of complex trait like learning and memory have been well studied over the decades. Through those groundbreaking findings, we now have a better understanding about some of the genes and pathways that are involved in learning and/or memory. However, few of these findings identified the naturally segregating variants that are influencing learning and/or memory within populations. In this special issue honoring the legacy of Troy Zars, we review some of the traditional approaches that have been used to elucidate the genetic basis of learning and/or memory, specifically in fruit flies. We highlight some of his contributions to the field, and specifically describe his vision to bring together behavior and quantitative genomics with the aim of expanding our knowledge of the genetic basis of both learning and memory. Finally, we present some of our recent work in this area using a multiparental population (MPP) as a case study and describe the potential of this approach to advance our understanding of neurogenetics.

中文翻译:

学习合作:将行为和定量基因组学结合起来。

几十年来,人们对学习和记忆等复杂特征的遗传基础进行了深入研究。通过这些突破性的发现,我们现在对参与学习和/或记忆的一些基因和途径有了更好的了解。然而,这些发现中很少有发现影响人群学习和/或记忆的自然分离变体。在这本纪念特洛伊扎尔斯遗产的特刊中,我们回顾了一些用于阐明学习和/或记忆的遗传基础的传统方法,特别是在果蝇中。我们重点介绍了他对该领域的一些贡献,并具体描述了他将行为和数量基因组学结合起来的愿景,目的是扩大我们对学习和记忆遗传基础的了解。最后,
更新日期:2020-01-10
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