BACKGROUND Histiocytic sarcoma affecting the central nervous system (CNS HS) in dogs may present as primary or disseminated disease, often characterized by inflammation. Prognosis is poor, and imaging differentiation from other CNS tumors can be problematic. OBJECTIVE To characterize the clinicopathological inflammatory features, breed predisposition, and survival in dogs with CNS HS. ANIMALS One hundred two dogs with HS, 62 dogs with meningioma. METHODS Retrospective case series. Records were reviewed for results of cerebrospinal fluid (CSF) analysis, CBC, treatment, and outcome data. RESULTS Predisposition for CNS HS was seen in Bernese Mountain Dogs, Golden Retrievers, Rottweilers, Corgis, and Shetland Sheepdogs (P ≤ .001). Corgis and Shetland Sheepdogs had predominantly primary tumors; Rottweilers had exclusively disseminated tumors. Marked CSF inflammation was characteristic of primary rather than disseminated HS, and neoplastic cells were detected in CSF of 52% of affected dogs. Increased neutrophil to lymphocyte ratios were seen in all groups relative to controls (P <.008) but not among tumor subtypes. Definitive versus palliative treatment resulted in improved survival times (P < .001), but overall prognosis was poor. CONCLUSIONS AND CLINICAL IMPORTANCE Clinicopathological differences between primary and disseminated HS suggest that tumor biological behavior and origin may be different. Corgis and Shetland Sheepdogs are predisposed to primary CNS HS, characterized by inflammatory CSF. High total nucleated cell count and the presence of neoplastic cells support the use of CSF analysis as a valuable diagnostic test. Prognosis for CNS HS is poor, but further evaluation of inflammatory mechanisms may provide novel therapeutic opportunities.

中文翻译：

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影响犬中枢神经系统的组织细胞肉瘤的临床病理特征。

背景技术影响犬中枢神经系统（CNS HS）的组织细胞肉瘤可能表现为原发性或传播性疾病，通常以炎症为特征。预后差，与其他中枢神经系统肿瘤的影像学鉴别可能存在问题。目的表征中枢神经系统HS的犬的临床病理炎症特征，品种易感性和存活率。动物一百零二只患有HS的狗，六十二只患有脑膜瘤的狗。方法回顾性病例系列。审查记录以了解脑脊液（CSF）分析，CBC，治疗和结果数据。结果在伯恩山犬，金毛寻回犬，罗威纳犬，柯基犬和设得兰群岛牧羊犬中发现了CNS HS的易感性（P≤.001）。柯基犬和设得兰群岛牧羊犬主要患有原发性肿瘤。罗威纳犬专门扩散了肿瘤。明显的脑脊液炎症是原发性而非弥漫性HS的特征，在52％患病犬的脑脊液中检测到赘生性细胞。相对于对照组，所有组中性粒细胞与淋巴细胞的比率均增加（P <.008），但在肿瘤亚型中却没有。明确治疗与姑息治疗可提高生存时间（P <.001），但总体预后较差。结论和临床意义原发性和散发性HS之间的临床病理学差异提示肿瘤生物学行为和起源可能不同。柯基犬和设得兰群岛牧羊犬倾向于以炎症性脑脊液为特征的原发性CNS HS。高总有核细胞计数和肿瘤细胞的存在支持将CSF分析用作有价值的诊断测试。CNS HS的预后很差，