BACKGROUND Dogs infected with canine parvovirus (CPV) have compromised intestinal epithelial barrier integrity. Production of D-lactate by enteric bacteria may directly reflect disease severity or contribute to metabolic acid-base status in these dogs. HYPOTHESIS Serum D-lactate concentration will be increased in CPV dogs compared to healthy controls and correlate with markers of disease severity and acid-base status. ANIMALS Dogs with CPV undergoing treatment (n = 40) and healthy control dogs (n = 9). METHODS Prospective observational study. Dogs with CPV had a baseline and daily CBC, venous blood gas with serum electrolyte concentrations, composite clinical severity score, and serum D-lactate concentration performed. A single serum D-lactate measurement was obtained from healthy control dogs. RESULTS The CPV dogs had a higher D-lactate concentration (mean ± SD) of 469 ± 173 μM compared to controls, 306 ± 45 μM (P < .001). There was no difference in baseline D-lactate concentrations for CPV survivors (474 ± 28 μM), versus nonsurvivors (424 ± 116 μM; P = .70). D-lactate concentration decreased over the first 4 days of treatment (-9.6 μM/d; P = .46). Dogs hospitalized for <4 days had lower baseline D-lactate concentrations compared to those hospitalized ≥4 days (400 ± 178 μM versus 520 ± 152 μM; P = .03). No sustained correlation over time between serum D-lactate concentration and clinical severity score or recorded acid-base results. CONCLUSIONS AND CLINICAL IMPORTANCE Serum D-lactate concentrations are higher in dogs with CPV compared to healthy controls but do not appear to be clinically relevant. No relationship identified between serum D-lactate concentrations and markers of CPV disease severity, acid-base status, or outcome.

中文翻译：

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细小病毒性肠炎犬的血清D-乳酸浓度。

背景技术被犬细小病毒（CPV）感染的狗已经损害了肠上皮屏障的完整性。肠细菌产生的D-乳酸可能直接反映疾病的严重性或有助于这些犬的代谢酸碱状态。假设与健康对照组相比，CPV狗的血清D-乳酸浓度会增加，并且与疾病严重程度和酸碱状态的标志物相关。动物接受CPV治疗的犬（n = 40）和健康对照犬（n = 9）。方法进行前瞻性观察研究。患有CPV的狗的基线和每日CBC，静脉血气，血清电解质浓度，综合临床严重程度评分和血清D-乳酸浓度均已执行。从健康对照犬获得单次血清D-乳酸盐测量。结果与对照组的306±45μM相比，CPV犬的D-乳酸浓度更高（平均值±SD）为469±173μM（P <.001）。CPV存活者的基线D-乳酸浓度（474±28μM）与非存活者的基线D-乳酸浓度（424±116μM; P = .70）没有差异。在治疗的前4天中，D-乳酸浓度降低（-9.6μM/ d； P = 0.46）。与住院≥4天的狗相比，住院<4天的狗的基线D-乳酸浓度较低（400±178μM对520±152μM； P = .03）。血清D-乳酸浓度与临床严重程度评分或记录的酸碱结果之间无持续相关性。结论和临床意义与健康对照组相比，CPV犬的血清D-乳酸浓度更高，但似乎与临床无关。