OBJECTIVES This review fills the paucity of information on K. pneumoniae as a nosocomial pathogen by providing pooled data on epidemiological risk factors, resistant trends and profiles and resistant and virulent genes of this organism in Asia. METHODS Exhaustive search was conducted using PubMed, Web of Science, and Google scholar for most studies addressing the prevalence, risk factors, drug resistant-mediated genes and/or virulent factors of K. pneumoniae in Asia. Data extracted for meta-analysis were analyzed using comprehensive meta-analysis version 3. Trends data for the isolation rate and resistance rates were entered into Excel spread sheet and the results were presented in graphs. RESULTS The prevalence rate of drug resistance in K. pneumoniae were; amikacin (40.8%) [95% CI 31.9-50.4], aztreonam (73.3%) [95% CI 59.9-83.4], ceftazidime (75.7%) [95% CI 65.4-83.6], ciprofloxacin (59.8%) [95% CI 48.6-70.1], colistin (2.9%) [95% CI 1.8-4.4], cefotaxime (79.2%) [95% CI 68.0-87.2], cefepime (72.6) [95% CI 57.7-83.8] and imipenem (65.6%) [95% CI 30.8-89.0]. TEM (39.5%) [95% CI 15.4-70.1], SHV-11 (41.8%) [95% CI 16.2-72.6] and KPC-2 (14.6%) [95% CI 6.0-31.4] were some of the resistance mediated genes observed in this study. The most virulent factors utilized by K. pneumoniae are; hypermucoviscous phenotype and mucoviscosity-related genes, genes for biosynthesis of lipopolysaccharide, iron uptake and transport genes and finally, adhesive genes. CONCLUSION It can be concluded that, antimicrobial resistant in K. pneumoniae is a clear and present danger in Asia which needs strong surveillance to curb this menace. It is very important for public healthcare departments to monitor and report changes in antimicrobial-resistant isolates.

中文翻译：

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肺炎克雷伯菌：对公共健康的威胁日益增加。

目的本综述通过提供有关亚洲该生物的流行病学危险因素，耐药趋势和概况以及耐药和强毒基因的汇总数据，填补了有关肺炎克雷伯菌作为医院病原体的信息不足的信息。方法使用PubMed，Web of Science和Google Scholar进行详尽搜索，以研究亚洲肺炎克雷伯菌的患病率，危险因素，药物介导的基因和/或毒性因素。使用综合的荟萃分析版本3对提取用于荟萃分析的数据进行分析。将隔离率和耐药率的趋势数据输入Excel电子表格，并将结果显示在图表中。结果肺炎克雷伯菌的耐药率分别为。阿米卡星（40.8％）[95％CI 31.9-50.4]，氨曲南（73.3％）[95％CI 59.9-83.4]，头孢他啶（75.7％）[95％CI 65.4-83.6]，环丙沙星（59.8％）[95％CI 48.6-70.1]，粘菌素（2.9％）[95％CI 1.8-4.4]，头孢噻肟（79.2％）[95％ CI 68.0-87.2]，头孢吡肟（72.6）[95％CI 57.7-83.8]和亚胺培南（65.6％）[95％CI 30.8-89.0]。TEM（39.5％）[95％CI 15.4-70.1]，SHV-11（41.8％）[95％CI 16.2-72.6]和KPC-2（14.6％）[95％CI 6.0-31.4]是其中的一些抵抗力这项研究中观察到的介导基因。肺炎克雷伯菌利用的最强毒因子是：高粘液黏性表型和粘液黏性相关基因，脂多糖的生物合成基因，铁的摄取和转运基因，最后是粘附基因。结论可以得出结论，在亚洲，肺炎克雷伯菌的耐药性是一个明显的现存危险，需要进行严密监视以遏制这种威胁。