Activation of NPY receptor subtype 1 by [D-His26]NPY is sufficient to prevent development of anxiety and depressive like effects in the single prolonged stress rodent model of PTSD,Neuropeptides

当前位置： X-MOL 学术 › Neuropeptides › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Activation of NPY receptor subtype 1 by [D-His26]NPY is sufficient to prevent development of anxiety and depressive like effects in the single prolonged stress rodent model of PTSD
Neuropeptides ( IF 2.5 ) Pub Date : 2020-04-01 , DOI: 10.1016/j.npep.2019.102001
Chiso Nwokafor ₁ , Lidia I Serova ₁ , Roxanna J Nahvi ₁ , Jaclyn McCloskey ₁ , Esther L Sabban ₁

Affiliation

The neuropeptide Y (NPY) system plays an important role in mediating resilience to the harmful effect of stress in post-traumatic stress disorder (PTSD). It can mediate its effects via several G-protein coupled receptors: Y1R, Y2R, Y4R and Y5R. To investigate the role of individual NPY receptors in the resilience effects of NPY to traumatic stress, intranasal infusion of either Y1R agonists [D-His26]NPY, [Leu31Pro34]NPY, Y2R agonist NPY (3-36) or NPY were administered to male Sprague-Dawley rats immediately following the last stressor of the single prolonged stress (SPS) protocol, a widely used PTSD animal model. After 7 or 14 days, effects of the treatments were measured on the elevated plus maze (EPM) for anxiety, in forced swim test (FST) for development of depressive-like or re-experiencing behavior, in social interaction (SI) test for impaired social behavior, and acoustic startle response (ASR) for hyperarousal. [D-His26]NPY, but not [Leu31Pro34]NPY nor NPY (3-36) Y2R, was effective in preventing the SPS-elicited development of anxiety. Y1R, but not Y2R agonists prevented development of depressive- feature on FST, with [D-His26]NPY superior to NPY. The results demonstrate that [D-His26]NPY was sufficient to prevent development of anxiety, social impairment and depressive symptoms, and has promise as an early intervention therapy following traumatic stress.

中文翻译：

[D-His26]NPY 激活 NPY 受体亚型 1 足以防止在 PTSD 的单一长期应激啮齿动物模型中出现焦虑和抑郁样效应

神经肽 Y (NPY) 系统在介导对创伤后应激障碍 (PTSD) 中压力有害影响的恢复力方面发挥重要作用。它可以通过几种 G 蛋白偶联受体介导其作用：Y1R、Y2R、Y4R 和 Y5R。为了研究单个 NPY 受体在 NPY 对创伤性压力的弹性影响中的作用，将 Y1R 激动剂 [D-His26]NPY、[Leu31Pro34]NPY、Y2R 激动剂 NPY (3-36) 或 NPY 鼻内输注给男性Sprague-Dawley 大鼠紧随单一长期压力 (SPS) 协议（一种广泛使用的 PTSD 动物模型）的最后一个压力源。7 或 14 天后，在高架十字迷宫 (EPM) 上测量治疗效果，用于焦虑，在强迫游泳测试 (FST) 中测量抑郁样或重新体验行为的发展，在社交行为受损的社交互动 (SI) 测试和过度觉醒的声学惊吓反应 (ASR) 测试中。[D-His26]NPY，但不是 [Leu31Pro34]NPY 或 NPY (3-36) Y2R，可有效防止 SPS 诱发的焦虑发展。Y1R，而不是 Y2R 激动剂阻止了 FST 抑郁特征的发展，[D-His26]NPY 优于 NPY。结果表明，[D-His26]NPY 足以预防焦虑、社交障碍和抑郁症状的发展，并有望作为创伤性压力后的早期干预疗法。[D-His26]NPY 优于 NPY。结果表明，[D-His26]NPY 足以预防焦虑、社交障碍和抑郁症状的发展，并有望作为创伤性压力后的早期干预疗法。[D-His26]NPY 优于 NPY。结果表明，[D-His26]NPY 足以预防焦虑、社交障碍和抑郁症状的发展，并有望作为创伤性压力后的早期干预疗法。

更新日期：2020-04-01

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11