BACKGROUND Proteinuria is a risk factor for progressive kidney injury in dogs. Enhanced understanding of potential associations between canine vector-borne diseases (CVBD) and proteinuria is needed. OBJECTIVES To determine the proportion of evaluated proteinuric dogs exposed to ≥1 CVBD, including Babesia spp., Ehrlichia spp., spotted-fever group Rickettsia, Bartonella spp., Anaplasma spp., hemotropic Mycoplasma spp., Borrelia burgdorferi, and Dirofilaria immitis, and to determine if demographic or clinicopathologic differences exist between proteinuric dogs exposed to CVBD versus proteinuric dogs with no evidence of CVBD exposure. ANIMALS Two-hundred nine proteinuric dogs, concurrently tested for CVBD, which were examined at a single academic veterinary hospital between January 2008 and December 2015. METHODS Retrospective cross-sectional study. Demographic, clinicopathologic, and CVBD test results were extracted from medical records. A multivariable logistic regression model was used to assess associations between CVBD and selected variables. RESULTS Based on serology and polymerase chain reaction testing, 34% of proteinuric dogs (72/209) were exposed to ≥1 CVBD. Exposure to Rickettsia spp. (19%), Ehrlichia spp. (12%), and B. burgdorferi (9%) were most common. The CVBD exposure was lower in dogs tested in autumn or spring, higher in intact dogs, and higher in dogs with lower serum albumin and higher serum creatinine concentrations. CONCLUSIONS AND CLINICAL IMPORTANCE Exposure to CVBD, particularly exposure to Rickettsia spp., Ehrlichia spp., and B. burgdorferi was found in proteinuric dogs from the southeast United States. Additional controlled prospective studies examining a potential causal relationship between CVBD and proteinuria are warranted.

中文翻译：

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美国东南部蛋白尿犬病媒传播疾病患病率的回顾性研究。

背景技术蛋白尿是犬进行性肾损伤的危险因素。需要加强对犬媒传播疾病（CVBD）和蛋白尿之间潜在关联的了解。目的确定暴露于≥1CVBD的蛋白尿犬的比例，包括巴贝斯菌，埃里希氏菌，斑点热组立克次氏菌，巴尔通体菌，无浆菌属，嗜血性支原体菌，伯氏疏螺旋体和狄罗菲里亚氏菌并确定在没有CVBD暴露证据的情况下，暴露于CVBD的蛋白尿狗与蛋白尿狗之间是否存在人口统计学或临床病理学差异。动物2008年1月至2015年12月，在同一家学术兽医医院对290例同时患有CVBD的蛋白尿狗进行了测试。方法回顾性横断面研究。人口统计学，临床病理学和CVBD测试结果均从病历中提取。多变量逻辑回归模型用于评估CVBD与所选变量之间的关联。结果根据血清学和聚合酶链反应测试，34％的蛋白尿狗（72/209）暴露于≥1 CVBD。暴露于立克次体 （19％），埃里希氏菌。（12％）和B. burgdorferi（9％）最常见。在秋季或春季测试的狗中，CVBD暴露量较低，完整犬中的CVBD暴露量较高，而血清白蛋白较低和血清肌酐浓度较高的犬中CVBD暴露量较高。结论和临床意义在美国东南部的蛋白尿犬中发现CVBD暴露，特别是暴露于立克次体，埃里希氏菌和B. burgdorferi。