Awareness of genetic risk in the Dominantly Inherited Alzheimer Network (DIAN),Alzheimer's & Dementia

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Awareness of genetic risk in the Dominantly Inherited Alzheimer Network (DIAN)
Alzheimer's & Dementia ( IF 13.0 ) Pub Date : 2020-01-01 , DOI: 10.1002/alz.12010
Andrew J Aschenbrenner ₁ , Bryan D James ₂ , Eric McDade ₁ , Guoqiao Wang ₃ , Yen Ying Lim ₄ , Tammie L S Benzinger _{1,

5} , Carlos Cruchaga _{1,

6} , Alison Goate ₇ , Chengjie Xiong _{1,

3} , Richard Perrin ₈ , Virginia Buckles ₁ , Ricardo Allegri ₉ , Sarah B Berman ₁₀ , Jasmeer P Chhatwal ₁₁ , Anne Fagan ₁ , Martin Farlow ₁₂ , Antoinette O'Connor ₁₃ , Bernardino Ghetti ₁₄ , Neill Graff-Radford ₁₅ , Jill Goldman ₁₆ , Susanne Gräber ₁₇ , Celeste M Karch _{1,

6} , Jae-Hong Lee ₁₈ , Johannes Levin _{19,

20} , Ralph N Martins _{21,

22} , Colin Masters ₄ , Hiroshi Mori ₂₃ , James Noble ₁₆ , Stephen Salloway ₂₄ , Peter Schofield _{25,

26} , John C Morris ₁ , Randall J Bateman ₁ , Jason Hassenstab ₁ , ₁

Affiliation

Charles F. and Joanne Knight Alzheimer's Disease Research Center, Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Rush Alzheimer's Disease Center, Rush University Medical Center, Department of Internal Medicine, Chicago, IL, USA.
Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.
Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Division of Neuropathology, Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA.
FLENI, Buenos Aires, Argentina.
Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA.
Dementia Research Centre, Queen Square Institute of Neurology, University College London, London, UK.
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.
Department of Neurology, Columbia University, New York, NY, USA.
German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany.
Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Perth, Australia.
Department of Biomedical Sciences, Macquarie University, Sydney, NSW, Australia.
Osaka City University Medical School, Asahi Machi Abenoku, Osaka, Japan.
Department of Neurology, Warren Alpert Medical School of Brown University, Providence, RI, USA.
Neuroscience Research Australia, Sydney, NSW, Australia.
School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.

Although some members of families with autosomal dominant Alzheimer's disease mutations learn their mutation status, most do not. How knowledge of mutation status affects clinical disease progression is unknown. This study quantifies the influence of mutation awareness on clinical symptoms, cognition, and biomarkers.

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