Introduction: 

Timely recognition of mild cognitive impairment (MCI) is essential in optimizing prevention and treatment for Alzheimer disease. Because of the paucity of data on MCI epidemiology in Greece and the variability of worldwide published results, we investigated the prevalence and determinants of MCI in the elderly population in Greece.

Methods: 

As part of the Hellenic Epidemiological Longitudinal Investigation of Aging and Diet (HELIAD), we randomly selected 1960 individuals 65 years and older to undergo full neurological and neuropsychological assessment by a multidisciplinary team. MCI was diagnosed according to the Petersen criteria.

Results: 

The age-standardized and gender-standardized prevalence of MCI in people aged 65 years and older in Greece is 13.11%. The amnestic and multidomain MCI subtypes are more common than their nonamnestic and single-domain counterparts, respectively. Almost two thirds of cases are because of suspected Alzheimer disease. Every additional year of age increases the odds of prevalent MCI by 7.4%, every additional year of education decreases the odds of MCI by 6.3%, and apolipoprotein E (APOE-ε4) carriage increases the odds of MCI by 57.9%.

Conclusions: 

MCI prevalence in the elderly population in Greece is on par with previously reported rates. Prospective studies with robust methodology will enhance our understanding of the dementia continuum.

中文翻译：

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希腊老年人中轻度认知障碍的患病率：HELIAD研究的结果。

介绍： 

及时识别轻度认知障碍（MCI）对于优化阿尔茨海默氏病的预防和治疗至关重要。由于希腊MCI流行病学数据的匮乏以及全球发表的结果的差异，我们调查了希腊老年人口中MCI的患病率和决定因素。

方法： 

作为古希腊饮食流行病学纵向调查（HELIAD）的一部分，我们随机选择了1960名65岁及65岁以上的个体，接受多学科团队的全面神经学和神经心理学评估。根据彼得森标准诊断出MCI。

结果： 

在希腊，年龄在65岁以上的MCI的年龄标准化和性别标准化的患病率为13.11％。记忆删除和多域MCI子类型分别比其非记忆删除和单域MCI亚型更常见。几乎三分之二的病例是由于疑似阿尔茨海默氏病。每增加一岁，普通MCI的几率增加7.4％，每增加一年接受教育，则MCI的几率降低6.3％，载脂蛋白E（APOE-ε4）携带使MCI的几率增加57.9％。

结论： 

希腊老年人口中的MCI患病率与先前报道的比率相当。运用可靠的方法进行前瞻性研究将增强我们对痴呆症连续体的理解。