Gammaherpesviruses are highly prevalent pathogens that establish life-long infection and are associated with diverse malignancies, including lymphoproliferative diseases and B cell lymphomas. Unlike other viruses that either do not infect B cells or infect B cells transiently, gammaherpesviruses manipulate physiological B cell differentiation to establish life-long infection in memory B cells. Disruption of such viral manipulation by genetic or environmental causes is likely to seed viral lymphomagenesis. In this review, we discuss physiological and unique host and viral mechanisms usurped by gammaherpesviruses to fine tune host B cell biology for optimal infection establishment and maintenance.

中文翻译：

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伽马疱疹病毒和B细胞：持续一生的关系。

γ疱疹病毒是高度流行的病原体，可建立终生感染并与多种恶性肿瘤相关，包括淋巴增生性疾病和B细胞淋巴瘤。与不感染B细胞或不能瞬时感染B细胞的其他病毒不同，γ疱疹病毒操纵生理B细胞分化以在记忆B细胞中建立终生感染。由于遗传或环境原因破坏这种病毒操作可能会导致病毒淋巴瘤的发生。在这篇综述中，我们讨论了伽玛疱疹病毒篡改的生理和独特的宿主和病毒机制，以微调宿主B细胞生物学，以实现最佳的感染建立和维持。