It is now clear that access to specific metabolic programmes controls the survival and function of various immune cell populations, including T cells. Efficient naïve and memory T cell homoeostasis requires the use of specific metabolic pathways and differentiation requires rapid and dramatic metabolic remodelling. While we are beginning to appreciate the crucial role of metabolic programming during normal T cell physiology, many of the potential impacts of ageing on metabolic homoeostasis and remodelling in T cells remain unexplored. This review will outline our current understanding of T cell metabolism and explore age-related metabolic changes that are postulated or have been demonstrated to impact T cell function.

中文翻译：

---

时钟在滴答滴答：衰老对T细胞代谢的影响。

现在清楚的是，进入特定代谢程序可控制包括T细胞在内的各种免疫细胞群体的存活和功能。有效的幼稚和记忆性T细胞稳态需要使用特定的代谢途径，而分化则需要快速而戏剧性的代谢重塑。尽管我们开始认识到在正常T细胞生理过程中代谢编程的关键作用，但衰老对T细胞代谢同质化和重塑的许多潜在影响仍未探索。这篇综述将概述我们目前对T细胞代谢的理解，并探讨被假定或已证明会影响T细胞功能的与年龄相关的代谢变化。