Gestational hypertension is one of the complicated disorders during pregnancy; it causes the significant risks, such as placental abruption, neonatal deaths, and maternal deaths. Hypertension is also responsible for the metabolic and cardiovascular issues to the mother after the years of pregnancy. Identifying and treating gestational hypertension during pregnancy by a suitable biomarker is mandatory for the healthy mother and foetus development. Cortisol has been found as a steroid hormone that is secreted by the adrenal gland and plays a pivotal role in gestational hypertension. A normal circulating level of cortisol is involved in the regulation of blood pressure, and it is necessary to monitor the changes in the level of cortisol during pregnancy. In this work, aptamer-based colorimetric assay is demonstrated as a model with gold nanorod to quantify the level of cortisol using the coordinated aggregation (at 500 mM of NaCl) and dispersion (with 10 μM of aptamer), evidenced by the scanning electron microscopy observation and UV-visible spectroscopy analysis. This colorimetric assay is an easier visual detection and reached the limit of detection of cortisol at 0.25 mg/mL. This method is reliable to identify the condition of gestational hypertension during the pregnancy period.

中文翻译：

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金纳米棒在适体介导的妊娠高血压分析中的协调分散和聚集。


妊娠期高血压是妊娠期复杂疾病之一。它会导致胎盘早剥、新生儿死亡和孕产妇死亡等重大风险。高血压还会导致母亲在怀孕数年后出现代谢和心血管问题。为了母亲和胎儿的健康发育，必须通过合适的生物标志物在怀孕期间识别和治疗妊娠高血压。皮质醇被发现是一种类固醇激素，由肾上腺分泌，在妊娠高血压中起着关键作用。正常的皮质醇循环水平参与血压的调节，因此有必要在怀孕期间监测皮质醇水平的变化。在这项工作中，基于适体的比色测定被证明是一种金纳米棒模型，可使用协调聚集（500 mM 氯化钠）和分散（10 μM 适体）来量化皮质醇水平，并由扫描电子显微镜证明观察和紫外可见光谱分析。该比色测定法更容易目视检测，并且皮质醇的检测限达到 0.25 mg/mL。该方法对于鉴别妊娠期​​妊娠高血压状况是可靠的。