A needle-type microrobot (MR) for targeted drug delivery is developed to stably deliver drugs to a target microtissue (MT) for a given period time without the need for an external force after affixing. The MRs are fabricatedby 3D laser lithography and nickel (Ni)/titanium oxide (TiO2 ) layers are coated by physical vapor deposition. The translational velocity of the MR is 714 µm s-1 at 20 mT and affixed to the target MT under the control of a rotating magnetic field. The manipulability of the MR is shown by using both manual and automatic controls. Finally, drug release from the paclitaxel-loaded MR is characterized to determine the efficiency of targeted drug delivery. This study demonstrates the utility of the proposed needle-type MR for targeted drug delivery to MT with various flow rates in vitro physiological fluidic environments.

中文翻译：

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通过固定在微组织上进行靶向药物输送的针型微型机器人。

开发了用于靶向药物递送的针型微型机器人（MR），以在给定的时间段内将药物稳定地递送至目标微组织（MT），而在粘贴后不需要外力。通过3D激光光刻技术制造MR，并通过物理气相沉积法涂覆镍（Ni）/二氧化钛（TiO2）层。MR在20 mT时的平移速度为714 µm s-1，并在旋转磁场的控制下固定在目标MT上。通过使用手动和自动控制来显示MR的可操作性。最后，从载有紫杉醇的MR中释放药物的特征在于确定靶向药物递送的效率。这项研究证明了所提出的针型MR在体外生理流体环境中以各种流速靶向药物向MT输送的实用性。