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The relationship between liver triglyceride composition and proton density fat fraction as assessed by 1 H MRS.
NMR in Biomedicine ( IF 2.7 ) Pub Date : 2020-03-03 , DOI: 10.1002/nbm.4286 Gavin Hamilton 1 , Alex N Schlein 1 , Tanya Wolfson 2 , Guilherme M Cunha 1 , Kathryn J Fowler 1 , Michael S Middleton 1 , Rohit Loomba 3, 4 , Claude B Sirlin 1
NMR in Biomedicine ( IF 2.7 ) Pub Date : 2020-03-03 , DOI: 10.1002/nbm.4286 Gavin Hamilton 1 , Alex N Schlein 1 , Tanya Wolfson 2 , Guilherme M Cunha 1 , Kathryn J Fowler 1 , Michael S Middleton 1 , Rohit Loomba 3, 4 , Claude B Sirlin 1
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The aim of this study was to estimate parameters determining liver triglyceride composition (TC) using 1 H MRS and to assess how TC estimability is affected by proton density fat fraction (PDFF) in adults with nonalcoholic fatty liver disease (NAFLD). In this prospective single-site study, 199 adults with known or suspected NAFLD in whom other causes of liver disease were excluded underwent two 1 H MRS STimulated Echo Acquisition Method (STEAM) sequences at 3 T. A respiratory-gated water-suppressed free breathing sequence (TE 10 ms, 16 signal averages) was used to assess TC in terms of the number of double bonds (ndb) and methylene-interrupted double bonds (nmidb), and a single breath-hold-long TR, multi-TE sequence (TR 3500 ms), which acquired five single average spectra over TE 10-30 ms, was used to estimate liver PDFF. Ndb and nmidb estimability was qualitatively assessed for each case and summarized descriptively. The consistency of ndb and nmidb estimation was examined using ROC analysis. The relationship between ndb and nmidb values and PDFF was presented graphically. Quality-of-fit of ndb and nmidb versus PDFF was evaluated by Pearson-r correlation. A significance level of 0.05 was used. In 263 1 H MRS examinations performed on 199 adult participants, ndb and nmidb were successfully estimated in 7/53 (13.2%) examinations with PDFF < 4%, 13/30 (43.3%) examinations with PDFF between 4% and 7%, 33/41 (80.5%) examinations with PDFF between 7% and 10%, and 124/139 (89.2%) examinations with PDFF > 10% (maximum PDFF 38.1%). Liver TC could be estimated consistently for PDFF > 6.7%. Both ndb and nmidb decreased with increasing PDFF (ndb = 2.83-0.0160·PDFF, r = -0.449, P < 0.0001); nmidb = 0.75-0.0088·PDFF, r = -0.350, P < 0.0001). In a cohort of adults with known or suspected NAFLD, liver TC becomes more saturated as PDFF increases.
中文翻译：
通过1 H MRS评估肝甘油三酸酯组成与质子密度脂肪分数之间的关系。
这项研究的目的是估计使用1 H MRS确定肝甘油三酸酯成分（TC）的参数，并评估非酒精性脂肪肝疾病（NAFLD）成年人的质子密度脂肪分数（PDFF）如何影响TC的可估计性。在这项前瞻性单点研究中，对199名已知或疑似NAFLD的成年人（其中排除了其他肝病的原因）在3 T时进行了两个1 H MRS模拟回波采集方法（STEAM）序列。呼吸门控水抑制自由呼吸根据双键（ndb）和亚甲基中断的双键（nmidb）的数目以及单屏屏气长TR，多TE序列，使用序列（TE 10 ms，16个信号平均值）评估TC。 （TR 3500 ms）在TE 10-30 ms内获得了五个单一的平均光谱，用于估算肝脏PDFF。定性评估每个案例的Ndb和nmidb可估计性，并进行描述性总结。使用ROC分析检查了ndb和nmidb估计的一致性。用图形表示了ndb和nmidb值与PDFF之间的关系。通过Pearson-r相关性评估了ndb和nmidb与PDFF的拟合质量。显着性水平为0.05。在对199位成年参与者进行的263 1 H MRS检查中，成功地估计了ndb和nmidb的7/53（13.2％）检查中PDFF <4％，13/30（43.3％）检查PDFF在4％和7％之间， PDFF介于7％至10％之间的检查为33/41（80.5％），PDFF> 10％（最大PDFF为38.1％）的124/139（89.2％）检查。对于PDFF> 6.7％，可以一致地估计肝脏TC。ndb和nmidb都随着PDFF的增加而降低（ndb = 2.83-0.0160 PDFF，r = -0.449，P <0.0001）; nmidb = 0.75-0.0088·PDFF，r = -0.350，P <0.0001）。在一群患有已知或疑似NAFLD的成年人中，随着PDFF的增加，肝TC变得更加饱和。
更新日期：2020-03-03
中文翻译：
通过1 H MRS评估肝甘油三酸酯组成与质子密度脂肪分数之间的关系。
这项研究的目的是估计使用1 H MRS确定肝甘油三酸酯成分（TC）的参数，并评估非酒精性脂肪肝疾病（NAFLD）成年人的质子密度脂肪分数（PDFF）如何影响TC的可估计性。在这项前瞻性单点研究中，对199名已知或疑似NAFLD的成年人（其中排除了其他肝病的原因）在3 T时进行了两个1 H MRS模拟回波采集方法（STEAM）序列。呼吸门控水抑制自由呼吸根据双键（ndb）和亚甲基中断的双键（nmidb）的数目以及单屏屏气长TR，多TE序列，使用序列（TE 10 ms，16个信号平均值）评估TC。 （TR 3500 ms）在TE 10-30 ms内获得了五个单一的平均光谱，用于估算肝脏PDFF。定性评估每个案例的Ndb和nmidb可估计性，并进行描述性总结。使用ROC分析检查了ndb和nmidb估计的一致性。用图形表示了ndb和nmidb值与PDFF之间的关系。通过Pearson-r相关性评估了ndb和nmidb与PDFF的拟合质量。显着性水平为0.05。在对199位成年参与者进行的263 1 H MRS检查中，成功地估计了ndb和nmidb的7/53（13.2％）检查中PDFF <4％，13/30（43.3％）检查PDFF在4％和7％之间， PDFF介于7％至10％之间的检查为33/41（80.5％），PDFF> 10％（最大PDFF为38.1％）的124/139（89.2％）检查。对于PDFF> 6.7％，可以一致地估计肝脏TC。ndb和nmidb都随着PDFF的增加而降低（ndb = 2.83-0.0160 PDFF，r = -0.449，P <0.0001）; nmidb = 0.75-0.0088·PDFF，r = -0.350，P <0.0001）。在一群患有已知或疑似NAFLD的成年人中，随着PDFF的增加，肝TC变得更加饱和。
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