当前位置：
X-MOL 学术
›
J. Mater. Chem. B
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Modified Ti3C2 nanosheets as peroxidase mimetics for use in colorimetric detection and immunoassays.
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020/03/04 , DOI: 10.1039/d0tb00239a Xiaoju Wu 1 , Tongming Chen 1 , Yuan Chen 1 , Guowei Yang 1
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020/03/04 , DOI: 10.1039/d0tb00239a Xiaoju Wu 1 , Tongming Chen 1 , Yuan Chen 1 , Guowei Yang 1
Affiliation
|
Since being discovered in 2011, a large class of two-dimensional materials, labeled MXenes, has received increased research enthusiasm both theoretically and experimentally due to the unique physical, optical and electrical properties. Here, we prepared few-layered Ti3C2 nanosheets by a facile two-step liquid exfoliation method and, for the first time, demonstrated their intrinsic peroxidase-like activity in a Ti3C2-TMB-H2O2 system. The as-produced Ti3C2 nanosheets, especially after histidine modification, were characterized with excellent water dispersibility, large specific surface area, and high stability, which contribute to their much higher affinity to both substrates when compared to HRP. We have also established the catalytic mechanism whereby Ti3C2 nanosheets, where Ti switched spontaneously from an oxidized to reduced state, promoted the electron transfer from TMB to H2O2. Given the color reaction of Ti3C2 nanosheets, we have fabricated a colorimetric paper-based sensor integrated with a smartphone to detect glucose and an immunoassay to detect IR-β, enabling Ti3C2 nanosheets to be a powerful tool in the biodetection field.
中文翻译：
修饰的Ti3C2纳米片作为过氧化物酶模拟物，用于比色检测和免疫测定。
自2011年被发现以来，由于其独特的物理，光学和电学性质，被标记为MXenes的大量二维材料在理论上和实验上都受到了越来越多的研究热情。在这里，我们通过简便的两步液体剥落方法制备了几层Ti3C2纳米片，并首次在Ti3C2-TMB-H2O2系统中证明了它们固有的过氧化物酶样活性。所生产的Ti3C2纳米片，特别是在组氨酸修饰后，具有优异的水分散性，大的比表面积和高稳定性，与HRP相比，对两个基材的亲和力更高。我们还建立了Ti3C2纳米片的催化机制，其中Ti自发地从氧化态转变为还原态，促进了电子从TMB转移到H2O2。考虑到Ti3C2纳米片的显色反应，我们制造了一种比色纸基传感器，该传感器与智能手机集成在一起以检测葡萄糖，并通过免疫测定法检测IR-β，从而使Ti3C2纳米片成为生物检测领域的强大工具。
更新日期：2020-04-01
中文翻译：
修饰的Ti3C2纳米片作为过氧化物酶模拟物，用于比色检测和免疫测定。
自2011年被发现以来，由于其独特的物理，光学和电学性质，被标记为MXenes的大量二维材料在理论上和实验上都受到了越来越多的研究热情。在这里，我们通过简便的两步液体剥落方法制备了几层Ti3C2纳米片，并首次在Ti3C2-TMB-H2O2系统中证明了它们固有的过氧化物酶样活性。所生产的Ti3C2纳米片，特别是在组氨酸修饰后，具有优异的水分散性，大的比表面积和高稳定性，与HRP相比，对两个基材的亲和力更高。我们还建立了Ti3C2纳米片的催化机制，其中Ti自发地从氧化态转变为还原态，促进了电子从TMB转移到H2O2。考虑到Ti3C2纳米片的显色反应，我们制造了一种比色纸基传感器，该传感器与智能手机集成在一起以检测葡萄糖，并通过免疫测定法检测IR-β，从而使Ti3C2纳米片成为生物检测领域的强大工具。
京公网安备 11010802027423号