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Intact NMR spectroscopy: slow high-resolution magic angle spinning chemical shift imaging.
Analyst ( IF 3.6 ) Pub Date : 2020/03/04 , DOI: 10.1039/d0an00118j
Covadonga Lucas-Torres 1 , Alan Wong
Affiliation  

High-Resolution Magic-Angle Spinning Chemical Shift Imaging (HR-MAS CSI) has recently been explored for nuclear magnetic resonance (NMR) metabolomics and shows considerable promise in organism research. This is due to its ability to offer a supplemental dimension - spatial metabolic distribution - for profiling. However, HR-MAS CSI suffers from the large centrifugal stress exerted on the sample, which inevitably hinders the metabolic assessment. Herein, a slow sample spinning strategy was implemented and evaluated. The results demonstrate its potential as a highly informative profiling approach for intact specimens, with high quality data and feasibility.

中文翻译:

完整的NMR光谱:慢速高分辨率幻角旋转化学位移成像。

高分辨率魔角旋转化学位移成像(HR-MAS CSI)最近已被开发用于核磁共振(NMR)代谢组学,在生物研究中显示出巨大的希望。这是因为它具有提供补充特征的能力-空间代谢分布-进行分析。然而,HR-MAS CSI遭受施加在样品上的巨大离心应力,这不可避免地阻碍了代谢评估。在本文中,实施并评估了慢速样品旋转策略。结果证明了其作为完整样本的高信息量分析方法的潜力,具有高质量的数据和可行性。
更新日期:2020-03-31
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