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Construction of a near-infrared responsive upconversion nanoplatform against hypoxic tumors via NO-enhanced photodynamic therapy
Nanoscale ( IF 5.8 ) Pub Date : 2020/03/04 , DOI: 10.1039/c9nr10453d Ying Lan 1 , Xiaohui Zhu , Ming Tang , Yihan Wu , Jing Zhang , Jinliang Liu , Yong Zhang
Nanoscale ( IF 5.8 ) Pub Date : 2020/03/04 , DOI: 10.1039/c9nr10453d Ying Lan 1 , Xiaohui Zhu , Ming Tang , Yihan Wu , Jing Zhang , Jinliang Liu , Yong Zhang
Affiliation
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Photodynamic therapy (PDT) has been extensively used to treat cancer and other malignant diseases because it can offer many unique advantages over other medical treatments such as less invasive, fewer side effects, lower cost, etc. Despite great progress, the efficiency of PDT treatment, as an oxygen-dependent therapy, is still limited by the hypoxic microenvironment in the human tumor region. In this work, we have developed a near-infrared (NIR) activated theranostic nanoplatform based on upconversion nanoparticles (UCNPs), which incorporates PDT photosensitizer (curcumin) and NO donor (Roussin's black salt) in order to overcome hypoxia-associated resistance by reducing cellular respiration with NO presence in the PDT treatment. Our results suggest that the photo-released NO upon NIR illumination can greatly decrease the oxygen consumption rate and hence increase singlet oxygen generation, which ultimately leads to an increased number of cancer cell deaths, especially under hypoxic condition. It is believed that the methodology developed in this study enables to relieve the hypoxia-induced resistance in PDT treatment and also holds great potential for overcoming hypoxia challenges in other oxygen-dependent therapies.
中文翻译：
通过 NO 增强光动力疗法构建近红外响应上转换纳米平台以对抗缺氧肿瘤
光动力疗法 (PDT) 已被广泛用于治疗癌症和其他恶性疾病，因为它可以提供许多比其他医学治疗独特的优势，例如侵入性小、副作用少、成本低等. 尽管取得了很大进展，但作为一种氧依赖性疗法，PDT 治疗的效率仍然受到人类肿瘤区域缺氧微环境的限制。在这项工作中，我们开发了一种基于上转换纳米粒子 (UCNPs) 的近红外 (NIR) 激活治疗诊断纳米平台，该平台结合了 PDT 光敏剂（姜黄素）和 NO 供体（Roussin 黑盐），以通过减少来克服缺氧相关的抵抗力PDT 治疗中不存在的细胞呼吸。我们的结果表明，在 NIR 照射下光释放的 NO 可以大大降低耗氧率，从而增加单线态氧的产生，最终导致癌细胞死亡数量增加，尤其是在缺氧条件下。
更新日期：2020-04-09
中文翻译：
通过 NO 增强光动力疗法构建近红外响应上转换纳米平台以对抗缺氧肿瘤
光动力疗法 (PDT) 已被广泛用于治疗癌症和其他恶性疾病，因为它可以提供许多比其他医学治疗独特的优势，例如侵入性小、副作用少、成本低等. 尽管取得了很大进展，但作为一种氧依赖性疗法，PDT 治疗的效率仍然受到人类肿瘤区域缺氧微环境的限制。在这项工作中，我们开发了一种基于上转换纳米粒子 (UCNPs) 的近红外 (NIR) 激活治疗诊断纳米平台，该平台结合了 PDT 光敏剂（姜黄素）和 NO 供体（Roussin 黑盐），以通过减少来克服缺氧相关的抵抗力PDT 治疗中不存在的细胞呼吸。我们的结果表明，在 NIR 照射下光释放的 NO 可以大大降低耗氧率，从而增加单线态氧的产生，最终导致癌细胞死亡数量增加，尤其是在缺氧条件下。
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